17094-01-8
中文名稱
L-墨蝶呤
英文名稱
L-SEPIAPTERIN
CAS
17094-01-8
分子式
C9H11N5O3
分子量
237.22
MOL 文件
17094-01-8.mol
更新日期
2024/10/25 11:17:12
17094-01-8 結(jié)構(gòu)式
基本信息
中文別名
墨蝶呤L-墨蝶呤
S-(-)-2-氨基-7,8-二氫-6-(2-羥基-1-氧代丙基)-4(1H)-蝶啶酮
英文別名
SEPIAPTERINL-SEPIAPTERIN
L-Sepiapterin,98%
Sepiapterin solid
L-SEPIAPTERIN DIHYDRATE
L -SEPIAPTERIN DIHYDRATE 99+%
SEPIAPTERIN (L-SEPIAPTERIN) COFACTOR OF NITRIC OX
2-amino-6-(2-hydroxypropanoyl)-7,8-dihydro-1H-pty oeridin-4-one
(S)-2-aMino-6-(2-hydroxypropanoyl)-7,8-dihydropteridin-4(1H)-one
2-AMINO-7,8-DIHYDRO-6-(2S-HYDROXY-1-OXOPROPYL)-4(1H)-PTERIDINONE
物理化學(xué)性質(zhì)
熔點>270 °C (dec.)
沸點448.1±55.0 °C(Predicted)
密度1.86±0.1 g/cm3(Predicted)
儲存條件−20°C
溶解度DMSO: 27 mg/mL
酸度系數(shù)(pKa)12.33±0.20(Predicted)
形態(tài)solid
顏色yellow
穩(wěn)定性感光
CAS 數(shù)據(jù)庫17094-01-8
常見問題列表
生物活性
L-Sepiapterin (Sepiapterin) 是內(nèi)皮型一氧化氮合酶 (eNOS) 輔因子四氫生物喋呤 (BH4) 的前體。L-Sepiapterin 改善 db/db 小鼠腸系膜小動脈內(nèi)皮功能障礙，誘導(dǎo)血管生成。L-Sepiapterin 通過下調(diào) p70S6K 依賴性 VEGFR-2 表達抑制卵巢癌細(xì)胞增殖和遷移。靶點
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Human Endogenous Metabolite
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體外研究
L-Sepiapterin (Sepiapterin) (0.1-10 μM; 24 hpurs) Iinduces cell proliferation in a dose-dependent manner.
L-Sepiapterin (1-50 μM; 20 minutes) significantly inhibits the phosphorylation of VEGF-A-induced (50 ng/ml) p70
S6K
.
L-Sepiapterin inhibits VEGF-A-induced cell proliferation and migration through NO-independent mechanism.
Cell Proliferation Assay
| Cell Line: | SKOV-3 cells |
| Concentration: | 0.1, 1, 10 μM |
| Incubation Time: | 24 hours |
| Result: | Induced cell proliferation in a dose-dependent manner. |
體內(nèi)研究
Sepiapterin (10 mg/kg; p.o. (powder chow); daily for or 8 weeks) significantly improves the relaxation to Ach in small mesenteric arteries (SMA) from db/db mice.
| Animal Model: | Male C57BL/KsJ diabetic mice (db/db) |
| Dosage: | 10 mg/kg |
| Administration: | P.o. (powder chow); daily for or 8 weeks |
| Result: | Significantly improved the relaxation to Ach in SMA from db/db mice. |