151358-47-3
151358-47-3 結(jié)構(gòu)式
基本信息
4(二(1H-吲哚-3-基)甲基)苯酚
DIM-C-pPhOH
DIM-C-pPhOH(CDIM8)
4-(di(1H-indol-3-yl)Methyl)phenol
4-[bis(1H-indol-3-yl)methyl]phenol
Phenol, 4-(di-1H-indol-3-ylmethyl)-
1,1-Bis(3'-indolyl)-1-(p-hydroxyphenyl)methane
物理化學(xué)性質(zhì)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-112055 | 4(二(1H-吲哚-3-基)甲基)苯酚 DIM-C-pPhOH | 151358-47-3 | 1mg | 500元 |
| 2024/11/08 | HY-112055 | 4(二(1H-吲哚-3-基)甲基)苯酚 DIM-C-pPhOH | 151358-47-3 | 5mg | 750元 |
| 2024/11/08 | HY-112055 | 4(二(1H-吲哚-3-基)甲基)苯酚 DIM-C-pPhOH | 151358-47-3 | 10mM * 1mLin DMSO | 825元 |
常見問題列表
| Target | Value |
|
Nur77
(786-O cells based assay) | 13.0 μM |
|
Nur77
(ACHN cells based assay) | 13.6 μM |
DIM-C-pPhOH (7.5-20 μM; 24 hours; ACHN and 786-O cells) treatment significantly decreases cell proliferation.
DIM-C-pPhOH (20 μM; 24 hours; ACHN and 786-O cells) treatment induces Annexin V staining in ACHN and 786-O cells, confirming that DIM-C-pPhOH induce apoptosis, and also induces cleavage of caspases 7 and 8.
DIM-C-pPhOH (15-20 μM; 24 hours; ACHN and 786-O cells) treatment inhibits NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induces sestrin 2, activates AMPKα and inhibits activation of mTOR and downstream kinases.
DIM-C-pPhOH decreases expression of β1-integrin protein and mRNA and β1-integrin-dependent responses in MCF7, MDA-MB-231, and SKBR3 cells and also inhibits migration of the latter two cell lines.
Cell Proliferation Assay
| Cell Line: | ACHN and 786-O cells |
| Concentration: | 7.5 μM, 15 μM, 20 μM |
| Incubation Time: | 24 hours |
| Result: | Significantly decreased cell proliferation. |
Apoptosis Analysis
| Cell Line: | ACHN and 786-O cells |
| Concentration: | 20 μM |
| Incubation Time: | 24 hours |
| Result: | Induced apoptosis in ACHN and 786-O cells. |
Western Blot Analysis
| Cell Line: | ACHN and 786-O cells |
| Concentration: | 15 μM, 20 μM |
| Incubation Time: | 24 hours |
| Result: | Inhibited NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induced sestrin 2, activated AMPKα and inhibited activation of mTOR and downstream kinases. |
DIM-C-pPhOH (30 mg/kg; oral gavage; daily; for 50 days; male athymic nude mice) treatment results in a significant inhibition of tumor growth.
| Animal Model: | Male athymic nude mice (aged 6-7 weeks) injected with ACHN cells |
| Dosage: | 30 mg/kg/day |
| Administration: | Oral gavage; daily; for 50 days |
| Result: | Resulted in a significant inhibition of tumor growth. |