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147438-27-5

中文名稱 依維莫司雜質(zhì) DCP
英文名稱 Seco Rapamycin
CAS 147438-27-5
分子式 C51H79NO13
分子量 914.17
MOL 文件 147438-27-5.mol
更新日期 2024/10/30 10:22:45
147438-27-5 結(jié)構(gòu)式 147438-27-5 結(jié)構(gòu)式

基本信息

中文別名
SECO RAPAMYCIN&NBSP
(SYNONYMS: SECORAPAMYCIN A)
英文別名
Seco Rapamycin
Secorapamycin A
Seco Rapamycin 
(Synonyms: Secorapamycin A)
Secorapamycin A(Seco Rapamycin)
Secorapamycin A, Technical Grade DISCONTINUED PLEASE SEE R124010
2-Piperidinecarboxylic acid, 1-[2-oxo-2-[(2R,3R,6S)-tetrahydro-2-hydroxy-6-[(2S,3E,5E,7E,9S,11R,13R,14R,15E,17R,19E,21R)-14-hydroxy-22-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxo-3,5,7,15,19-docosapentaen-1-yl]-3-methyl-2H-pyran-2-yl]acetyl]-, (2E...
所屬類別
分析化學(xué):對照品

物理化學(xué)性質(zhì)

沸點965.7±75.0 °C(Predicted)
密度1.17±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)3.24±0.20(Predicted)

常見問題列表

生物活性
Seco Rapamycin (Secorapamycin A) 是 Rapamycin 的開環(huán)代謝物。Seco-Rapamycin 幾乎不影響 mTOR 功能。
體外研究

Disposition of Seco Rapamycin in Human Tissue Homogenates and Caco-2 Cell Monolayers. To determine whether Seco Rapamycin (D2) can be metabolized to dihydro Sirolimus (M2), 20μM Seco Rapamycin is incubated with human liver, jejunal mucosal, and Caco-2 homogenates. All of these homogenates produced M2 in an NADPH-dependent manner. Ketoconazole, at a high concentration (100μM), has no effect on the formation of M2 in any of the homogenates examined. To determine whether Seco Rapamycin can be metabolized to M2 in intact cells, 20μM Seco Rapamycin is added to Caco-2 cell monolayers. When applied to the apical compartment, little Seco Rapamycin is detected in the basolateral compartment and in the cellular fraction after 4 h. In addition, little M2 is detected. LY335979 has little effect on the distribution of Seco Rapamycin after an apical dose, although M2 became detectable in the apical compartment. In contrast, when Seco Rapamycin is applied to the basolateral compartment, both Seco Rapamycin and M2 are readily detected in the apical compartment; LY335679 decreases the flux of Seco Rapamycin to the apical compartment and increases the amount of M2 in both apical and basolateral compartments.

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