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1341224-83-6

中文名稱 INCB8761(PF-4136309)
英文名稱 INCB8761(PF-4136309)
CAS 1341224-83-6
分子式 C29H31F3N6O3
分子量 568.59
MOL 文件 1341224-83-6.mol
更新日期 2024/12/24 19:29:55
1341224-83-6 結(jié)構(gòu)式 1341224-83-6 結(jié)構(gòu)式

基本信息

中文別名
化合物PF4136309
英文別名
CS-1440
EOS-61910
NCB8761(PF-4136309)
INCB8761(PF-4136309)
PF-04136309(INCB-8761)
ZNSVOHSYDRPBGI-LXWOLXCRSA-N
N-(2-((S)-3-(((1R,4S)-4-HYDROXY-4-(5-(PYRIMIDIN-2-YL)
INCB8761
PF-4136309
PF4136309
PF 4136309
INCB-8761
N-(2-((S)-3-(((1r,4S)-4-hydroxy-4-(5-(pyrimidin-2-yl) yridine-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide
Benzamide, N-[2-[(3S)-3-[[trans-4-hydroxy-4-[5-(2-pyrimidinyl)-2-pyridinyl]cyclohexyl]amino]-1-pyrrolidinyl]-2-oxoethyl]-3-(trifluoromethyl)-
所屬類別
生物化工:激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

沸點(diǎn)712.2±60.0 °C(Predicted)
密度1.40±0.1 g/cm3(Predicted)
儲(chǔ)存條件Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度溶于 DMSO(至少 25 mg/ml)
酸度系數(shù)(pKa)13.17±0.46(Predicted)
形態(tài)固體
顏色米白色
穩(wěn)定性可在-20°C的DMSO中的溶液下儲(chǔ)存長(zhǎng)達(dá)3個(gè)月。

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
海關(guān)編碼2933998090

常見問題列表

生物活性
PF-4136309 是一種高效,選擇性,可口服的 CCR2 拮抗劑,能夠抑制人,小鼠和大鼠 CCR2,IC50 值分別為 5.2 nM,17 nM 和 13 nM。
靶點(diǎn)

Human CCR2

5.2 nM (IC 50 )

Mouse CCR2

13 nM (IC 50 )

Rat CCR2

17 nM (IC 50 )

體外研究

PF-4136309 is potent in human chemotaxis activity (IC 50 =3.9 nM) and in the whole blood assay (IC 50 =19 nM), with IC 50 of 16 and 2.8 nM in mouse and rat chemotaxis assays. PF-4136309 is potent in inhibiting CCR2 mediated signaling events such as intracellular calcium mobilization and ERK (extracellular signal-regulated kinase) phosphorylation with IC 50 values of 3.3 and 0.5 nM, respectively. In hERG patch clamp assay, PF-4136309 inhibits hERG potassium current with an IC 50 of 20 μM. PF-4136309 is not a cytochrome P450 (CYP) inhibitor, with IC 50 values of >30 μM against five major CYP isozymes CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4. Moreover, PF-4136309 is not a CYP inducer at concentrations up to 30 μM.

體內(nèi)研究

PF-4136309 (2 mg/kg) exhibits a moderate half-life in both species after iv administration (2.5 and 2.4 h). When administered orally, PF-4136309 (10 mg/kg) is absorbed rapidly, with peak concentration time (T max ) at 1.2 h for rats and 0.25 h for dogs. A similar half-life is observed in both species between iv dosing and po dosing. PF-4136309 is well absorbed, with an oral bioavailability of 78% in both species.

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