106861-44-3
中文名稱
米庫氯銨
英文名稱
Mivacurium chloride
CAS
106861-44-3
分子式
C58H80Cl2N2O14
分子量
1100.17
MOL 文件
106861-44-3.mol
更新日期
2024/12/25 19:46:29
106861-44-3 結(jié)構(gòu)式
基本信息
中文別名
氯米洼庫咪伐氯銨
米伐氯銨
米庫氯銨
米庫氯銨氯化物
-1,2,3,4-四氫-2-(3-羥丙基)-6,7-二甲氧基-2-甲基-1-(3,4,5-三甲基芐基)異喹啉氯化物(E)-4-辛烯二羧酸(2:1)
英文別名
MivacronBW-B1090U
rac-Mivacron
rac-BW-B 1090
rac-BW-B 1090U
MIVACURIUM CHLORIDE
rac Mivacurium Chloride
Mivacurium Chloride (mixture of isomers)
-1，2，3，4-Te．trahydro-2-(3-hydroxypropyl)-6，7-dimethoxy-2-methyl-1-(3，4，5-trimethoxy-benzyl)isoquinolinium chloride，(E)-4-octenedioate(2：1)
[R-[R*,R*-(E)]]2,2'-(1,8-Dioxo-4-octene-1,8-diyl)bis(oxy-3,1-propanediyl)bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxyphenyl)isoquinolinium] dichloride
所屬類別
原料藥：骨骼肌松弛藥物理化學(xué)性質(zhì)
外觀性狀無定形固體。[α]D20-62.7°(C=1.9，水)。
比旋光度20D -62.7° (c = 1.9 in water)
儲存條件Hygroscopic, -20°C Freezer, Under Inert Atmosphere
溶解度DMSO: Soluble; Water: Soluble
形態(tài)固體
顏色White to off-white
穩(wěn)定性吸濕性
InChIKeyKFWHZSUNFAPZPW-NVIAPQDINA-M
常見問題列表
生物活性
Mivacurium dichloride 是一種芐基異喹啉衍生物，也是一種短效非去極化神經(jīng)肌肉阻滯劑和骨骼肌松弛劑。Mivacurium dichloride 可與 nAChR 偶聯(lián)，以減少或抑制乙酰膽堿對肌肉細胞末端盤的去極化作用。體外研究
Mivacurium induces LAD2 cell degranulation in a dose-dependent manner. Mivacurium stimulates intracellular Ca 2+ influx in MRGPRX2-HEK293 cells but not in NC-HEK293 cells. Mivacurium induces the release of only low levels of mediators in LAD2 cells transfected with MRGPRX2-targeted small interfering siRNA.
體內(nèi)研究
Mivacurium causes pseudo-allergic reactions in C57 wild-type mice by inducing mast cells to release histamine and a decrease in body temperature.
Mivacurium is rapidly hydrolyzed in the plasma and has a short duration of action (< 10 min). Mivacurium has many advantages, such as a rapid effect, nonneurological toxicity and a lack of heart rate alteration.