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1001600-56-1

中文名稱(chēng) BV 6
英文名稱(chēng) BV6
CAS 1001600-56-1
分子式 C70H96N10O8.xCF3COOH
分子量 1205.57
MOL 文件 1001600-56-1.mol
更新日期 2024/06/07 17:53:10
1001600-56-1 結(jié)構(gòu)式 1001600-56-1 結(jié)構(gòu)式

基本信息

中文別名
化合物BV6
BV-6游離態(tài)
英文別名
BV6
CS-1501
CS-2877
BV-6
BV6
BV-6 TFA
CHEBI:47924
BV6 USP/EP/BP
CHEBI:47924
BV-6 BV 6
4,4'-(1,6-Hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-β-phenyl-L-Phenylalanin
L-Phenylalaninamide, 4,4'-(1,6-hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-β-phenyl-
所屬類(lèi)別
生物化工:IAP 抑制劑

物理化學(xué)性質(zhì)

沸點(diǎn)1376.7±65.0 °C(Predicted)
密度1.177±0.06 g/cm3(Predicted)
儲(chǔ)存條件Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度≥60.28 mg/mL in DMSO; insoluble in H2O; ≥12.6 mg/mL in EtOH with ultrasonic
酸度系數(shù)(pKa)12.89±0.20(Predicted)
形態(tài)固體
顏色White to off-white

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
防范說(shuō)明P261-P305+P351+P338

常見(jiàn)問(wèn)題列表

生物活性
BV-6是一種SMAC模擬的cIAP和XIAP的雙重抑制劑。
體外研究
BV6抑制HCC193 NSCLC細(xì)胞的細(xì)胞活性,IC50 為 7.2 μM,在HCC193 和H460細(xì)胞系引起細(xì)胞凋亡,并通過(guò)分別激活裂解的caspase-8 和caspase-9顯著增加這些細(xì)胞系的放射敏感性。在不成熟的樹(shù)突細(xì)胞中,BV-6治療導(dǎo)致經(jīng)典的NF-kB通路適度激活。此外,BV-6增加CIK細(xì)胞介導(dǎo)的血液病(H9,THP-1,和Tanoue)和固體腫瘤(RH1,RH30,和TE671)的消退。BV-6也會(huì)增強(qiáng)外周血單核細(xì)胞的凋亡,并且對(duì)免疫細(xì)胞限制其細(xì)胞毒性潛能具有顯著的抑制作用。
靶點(diǎn)

IAP

體內(nèi)研究

Murine cIAP-1, cIAP-2 and XIAP expressions are clearly observed in the cytoplasm of both epithelial and stromal cells of implants, whereas Survivin is mainly expressed in the nuclei BV6 treatment for 4 weeks attenuated the intensity of IAPs expression. The size of lesions range from ~2 to 7 mm in diameter. The monolayer epithelial cell lining of the cyst is shown. After immunohistochemical staining, cytokeratin and vimentin are positively stained, whereas calretinin is negative. After BV6 treatment for 4 weeks, the total number of lesions (4.6 versus 2.8/mouse), the average weight (78.1 versus 32.0 mg/mouse) and the surface area (44.5 versus 24.6 mm 2 /mouse) of lesions are significantly less than in the controls. In the endometrial gland epithelia or stroma, the percentage of Ki67-positive cells decreases after BV6 treatment.

圖譜信息

BV 6價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2025/02/08HY-16701BV61001600-56-11 mg453元
2025/02/08HY-16701BV 6
BV6
1001600-56-12mg621元
2025/02/08HY-16701BV 6
BV6
1001600-56-15mg836元
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