| Identification | More | [Name]
Hydroxyethyl Cellulose | [CAS]
9004-62-0 | [Synonyms]
2-HYDROXYETHYL CELLULOSE
CELLOSIZE WP-40
CELLULOSE, 2-HYDROXYETHYL ETHER
CELLULOSE, HYDROXYETHYL ETHER
HEC
HYDROXYETHYL CELLULOSE
HYDROXYETHYL-CELLULOSE 140'000-160'000
HYDROXYETHYL-CELLULOSE DYED WITH OSTAZIN BRILLIANT RED H-3B
Hydroxyethyl cellulose ether
2-hydroxyethylcelluloseether
ah15
aw15(polysaccharide)
aw15[polysaccharide]
bl15
cellosize
cellosize4400h16
cellosizeqp
cellosizeqp1500
cellosizeqp3
cellosizeqp30000 | [EINECS(EC#)]
618-387-5 | [Molecular Formula]
C29H52O21 | [MDL Number]
MFCD00072770 |
| Chemical Properties | Back Directory | [Definition]
A starch derivative containing 90% amylopectin. | [Appearance]
light yellow powder | [Melting point ]
288-290 °C (dec.)
| [density ]
0.75 g/mL at 25 °C(lit.)
| [storage temp. ]
room temp | [solubility ]
H2O: ≤5 wt. % at 20 °C
| [form ]
powder
| [color ]
Light brown powder | [Odor]
Odorless | [PH]
pH(20g/l,25℃) : 5.0～8.0 | [Stability:]
Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides | [Water Solubility ]
almost transparency | [Merck ]
4673 | [Uses]
hydroxyethyl cellulose is a thickener, protective colloid, binder, stabilizer, and suspending agent. It is obtained from wood pulp Copyright 2014 Cengage Learning. All Rights Reserved. May not be copied, scanned, or duplicated, in whole or in part. Due to electronic rights, some third party content may be suppressed from the eBook and/or eChapter(s). Editorial Review has deemed that any suppressed content does not materially affect the overall learning experience. Cengage Learning reserves the right to remove additional content at any time if subsequent rights restrictions require it. or chemical cotton by treatment with an alkali. | [CAS DataBase Reference]
9004-62-0(CAS DataBase Reference) | [EPA Substance Registry System]
9004-62-0(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S24/25:Avoid contact with skin and eyes .
S22:Do not breathe dust . | [WGK Germany ]
3
| [RTECS ]
FJ5958000
| [F ]
3 | [Autoignition Temperature]
725 °F | [HS Code ]
39123980 | [Hazardous Substances Data]
9004-62-0(Hazardous Substances Data) | [Toxicity]
LDLo intravenous in women: 5100mg/kg/6D- |
| Hazard Information | Back Directory | [Description]
Hetastarch, another nonproteinaceous colloid, is a complex mixture of ethoxylated amylopectins
ranging in molecular weight from 10 to 1,000 kDa (average molecular weight, ~450 kDa). When
infused as a 6% solution, hetastarch approximates the activity of human albumin. The larger
molecular weights, however, increase its intravascular residence time as well as its plasma
expansion effects relative to albumin.
Hetastarch is synthetically produced, so it is degraded more
slowly and is less antigenic than other colloids. Despite these advantages, hetastarch is quite
expensive and also has no oxygen-carrying capacity. | [Characteristics]
Hydroxyethyl cellulose is soluble in hot or cold water, and does not precipitate at high temperature or boiling, so it has a wide range of solubility and viscosity characteristics, as well as non-thermal gelling properties. Hydroxyethyl cellulose is a non-ionic polymer material , can coexist with a wide range of other water-soluble polymers, surfactants, and salts, and is an excellent colloidal thickener for high-concentration dielectric solutions. The water retention capacity of hydroxyethyl cellulose is twice that of methyl cellulose, and it has better flow regulation; the dispersing ability of hydroxyethyl cellulose is comparable to that of methyl cellulose and hydroxypropyl methyl cellulose The specific dispersing ability is the worst, but the protective colloid ability is the strongest. | [Preparation]
Hydroxyethylcellulose is prepared from alkali cellulose and ethylene oxide. It may be noted that the hydroxyethyl group itself can react with ethylene
oxide so that side-chains of varying length may be present in the product.
Commercial materials generally contain between 1.4 and 2.0 ethylene oxide
residues per glucose residue and have a degree of substitution of about 0.8-1.0. | [Brand name]
Hespan (DuPont Merck)
. | [General Description]
Non-ionic water soluble polymer. Aqueous solutions are pseudoplastic. Readily disperses without lumping. | [Pharmaceutical Applications]
Hydroxyethyl cellulose is a nonionic, water-soluble polymer widely
used in pharmaceutical formulations. It is primarily used as a
thickening agent in ophthalmic and topical formulations,
although it is also used as a binder and film-coating agent for
tablets.It is present in lubricant preparations for dry eye, contact
lens care, and dry mouth.
The concentration of hydroxyethyl cellulose used in a formulation
is dependent upon the solvent and the molecular weight of the
grade.
Hydroxyethyl cellulose is also widely used in cosmetics. | [Toxicology]
Considered to be non toxic. Use as a food additive indicates good tolerance of small amounts, but excessive amounts or overuse may bring irritant and /or harmful effects. Polysaccharides are not substantially absorbed from the gastrointestinal tract but may produce a laxative effect. | [Safety]
Hydroxyethyl cellulose is primarily used in ophthalmic and topical
pharmaceutical formulations. It is generally regarded as an
essentially nontoxic and nonirritant material.
Acute and subacute oral toxicity studies in rats have shown no
toxic effects attributable to hydroxyethyl cellulose consumption, the
hydroxyethyl cellulose being neither absorbed nor hydrolyzed in the
rat gastrointestinal tract. However, although used in oral pharmaceutical
formulations, hydroxyethyl cellulose has not been
approved for direct use in food products.
Glyoxal-treated hydroxyethyl cellulose is not recommended for
use in oral pharmaceutical formulations or topical preparations that
may be used on mucous membranes. Hydroxyethyl cellulose is also
not recommended for use in parenteral products. | [storage]
Hydroxyethyl cellulose powder is a stable though hygroscopic
material.
Aqueous solutions of hydroxyethyl cellulose are relatively stable
at pH 2–12 with the viscosity of solutions being largely unaffected.
However, solutions are less stable below pH 5 owing to hydrolysis.
At high pH, oxidation may occur.
Increasing the temperature reduces the viscosity of aqueous
hydroxyethyl cellulose solutions. However, on cooling, the original
viscosity is restored. Solutions may be subjected to freeze–thawing,
high-temperature storage, or boiling without precipitation or
gelation occurring.
Hydroxyethyl cellulose is subject to enzymatic degradation, with
consequent loss in viscosity of its solutions. Enzymes that catalyze
this degradation are produced by many bacteria and fungi present
in the environment. For prolonged storage, an antimicrobial
preservative should therefore be added to aqueous solutions.
Aqueous solutions of hydroxyethyl cellulose may also be sterilized
by autoclaving.
Hydroxyethyl cellulose powder should be stored in a well-closed
container, in a cool, dry place. | [Properties and Applications]
|
Index
|
Results
|
|
Appearance
|
White powder
|
|
Viscosity(mPa.s) 2% at 20℃,Brookfield 20rpm sp.5 cps
|
15,000-25,000
|
|
Particle size 80 mesh (180um) %
|
95.0 min
|
|
M.S.(Molar substitution degree) %
|
2.0-2.5
|
|
Moisture
％
|
≤6.0
|
|
Water insoluble %
|
≤0.5
|
|
pH
|
5.5-7.0
|
|
Ash Content %
|
≤5.0
|
|
Bulk density g/L
|
420-500
|
| [Incompatibilities]
Hydroxyethyl cellulose is insoluble in most organic solvents. It is
incompatible with zein and partially compatible with the following
water-soluble compounds: casein; gelatin; methylcellulose; polyvinyl
alcohol, and starch.
Hydroxyethyl cellulose can be used with a wide variety of watersoluble
antimicrobial preservatives. However, sodium pentachlorophenate
produces an immediate increase in viscosity when added
to hydroxyethyl cellulose solutions.
Hydroxyethyl cellulose has good tolerance for dissolved
electrolytes, although it may be salted out of solution when mixed
with certain salt solutions. For example, the following salt solutions
will precipitate a 10% w/v solution of Cellosize WP-09 and a 2%
w/v solution of Cellosize WP-4400: sodium carbonate 50% and
saturated solutions of aluminum sulfate; ammonium sulfate;
chromic sulfate; disodium phosphate; magnesium sulfate; potassium
ferrocyanide; sodium sulfate; sodium sulfite; sodium thiosulfate;
and zinc sulfate.
Natrosol is soluble in most 10% salt solutions, excluding sodium
carbonate and sodium sulfate, and many 50% salt solutions with
the exception of the following: aluminum sulfate; ammonium
sulfate; diammonium phosphate; disodium phosphate; ferric
chloride; magnesium sulfate; potassium ferrocyanide; sodium
metaborate; sodium nitrate; sodium sulfite; trisodium phosphate;
and zinc sulfate. Natrosol 150 is generally more tolerant of
dissolved salts than is Natrosol 250.
Hydroxyethyl cellulose is also incompatible with certain
fluorescent dyes or optical brighteners, and certain quaternary
disinfectants which will increase the viscosity of aqueous solutions. | [Regulatory Status]
Included in the FDA Inactive Ingredients Database (ophthalmic
preparations; oral syrups and tablets; otic and topical preparations).
Included in nonparenteral medicines licensed in the UK. Included in
the Canadian List of Acceptable Non-medicinal Ingredients.
Hydroxyethyl cellulose is not currently approved for use in food
products in Europe or the USA, although it is permitted for use in
indirect applications such as packaging. This restriction is due to the
high levels of ethylene glycol residues that are formed during the
manufacturing process. |
| Questions And Answer | Back Directory | [Thickeners and binders]
Hydroxyethyl cellulose is a commonly used cellulose ethers organic water-based ink thickening agent, belongs to a water-soluble non-ionic compound, with good water thickening ability, degraded by oxygen, acid and enzyme, under alkaline conditions can be crosslinked by Cu2 +. Has thermal stability, when heated, does not appear gelation, does not occur precipitation under acidic conditions, the film-forming property is good, the aqueous solution can be made of a transparent film, can be derived from the reaction of alkali cellulose with ethylene oxide, having properties such as thickening, emulsifying, adhesive, suspension, film-forming, maintaining moisture and protectiving colloid. The role of thickener in the aqueous ink is thickened. The viscosity of the ink added a thickening agent increases, can improve the physical and chemical stability of the ink; due to the increased viscosity, rheology of the ink can be controlled at the time of printing; the pigment and filler in ink is not easy to precipitate, increasing the storage stability of the water-based ink.
Thickening agent is a cellulose-based material and (or) polyvinyl alcohol substances. Cellulose substances may be methyl cellulose, ethyl cellulose, hydroxymethyl cellulose, carboxymethyl cellulose, hydroxypropyl cellulose, Hydroxyethyl cellulose and hydroxypropylmethyl cellulose; polyvinyl alcohol material may be an or several species of polyethylene 400, 600, 800, 1000, 1600, 2000, 4000, 6000.
The above information is edited by the chemicalbook of Liu Yujie. | [Chemical properties]
This product is white to yellowish fibrous or powdery solid, non-toxic, tasteless and soluble in water. Insoluble in common organic solvents. Having properties such as thickening, suspending, adhesive, emulsifying, dispersing, water holding. Different viscosity range of solution can be prepared. Having exceptionally good salt solubility to electrolyte. | [Uses]
1. This product is used for cracking method to extract polymerized dispersing agents such as oil water base gel fracturing fluid, polystyrene and polyvinyl chloride. Also for latex thickening agent in paint industry, hygristor in electronics industry, cement anti-coagulant agent and water retention agent in construction industry. Glazing in ceramic industry and toothpaste binder. Also widely used in many aspects such as printing and dyeing, textile, paper, pharmaceutical, health, food, cigarettes, pesticides and fire extinguishing agent.
2. Used as a water-based drilling fluids, and thickening agent and filtrate reducer of completion fluids, thickening agent has obvious effect on brine drilling fluid. Also can be used for filtrate reducer of oil well cement. Cross-linking with the polyvalent metal ions into a gel.
3. As surfactants, protective colloids, emulsion stabilizers in combination with emulsion such as vinyl chloride, vinyl acetate emulsion, and a tackifier, dispersant, dispersion stabilizer of emulsion. Widely used in many aspects such as coatings, fibers, dyeing, paper, cosmetics, pharmaceuticals, pesticides. There are many uses in oil exploitation and machinery industry.
4. As surfactants, latex thickening agent, protective colloid, oil exploitation fracturing fluid and polystyrene and polyvinyl chloride dispersing agents, etc. | [Production methods]
1. Alkali cellulose is a natural polymer, each of a fiber-based ring contains three hydroxyl groups, the most active hydroxyl reaction to give Hydroxyethyl cellulose. The raw material cotton linter or refined pulp meal were immersed in 30% liquid caustic soda, took out to squeeze after half an hour. Squeezed water containing soda to 1: 2.8, pulverized. Pulverized alkali cellulose was added into the reaction kettle, sealed, vacuumized, nitrogen charge, repeated to vacuumize and nitrogen charge to replace atmosphere in the reaction kettle. Precooled the liquid ethylene oxide was pressed into, cooling water was pumped in jacket of reaction kettle, controlled at about 25 ℃ and reacted for 2 h, crude product of Hydroxyethyl cellulose was obtained. The crude product was washed with alcohol, added acetic acid to adjust pH value to 4-6, added glyoxal to crosslink and aging. Then washed with water, centrifugal dewatering, dryed, milled to obtain Hydroxyethyl cellulose. Raw material consumption (kg/t) linter or low pulp meal 730-780 liquid caustic soda (30%) 2400 ethylene oxide 900 alcohol (95%) 4500 acetic acid 240 Glyoxal (40%) 100-300.
2. The raw material cotton linter or refined pulp meal were immersed in 30% liquid caustic soda, after half an hour took out to squeeze. Squeezed water containing soda to 1: 2.8, pulverized alkali cellulose was added into the reaction kettle, sealed and vacuumized, nitrogen charge, used nitrogen to replace all atmosphere in the reaction kettle,Precooled the liquid ethylene oxide was pressed into. In the cooling, controlled at 25 ℃ and reacted for 2 h, to give the crude product of crude Hydroxyethyl cellulose. The crude product was washed with ethanol and acetic acid was added to adjust the pH value to 4-6. added glyoxal to crosslink and aging, washed with water fast, finally centrifugal dehydration, dried, milled, obtained low salt Hydroxyethyl cellulose. |
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