| Identification | Back Directory | [Name]
Cellulose microcrystalline | [CAS]
9004-34-6 | [Synonyms]
cepo
la01
celufi
rexcel
AVIRIN
abicel
avicel
arbocel
kingcot
raywebq
tomofan
tunicin
cepocfm
cepos20
cepos40
cellexmx
heweten10
rayophane
sigmacell
solka-fil
avicel101
avicel102
AVICEL SF
AVICEL(R)
AVICEL PH
CELLULOSE
SOLKA-FLOC
elcemaf150
elcemag250
elcemap050
elcemap100
freseniusd6
onozukap500
avicelcl611
avicelph101
avicelph105
PAPERFIBRES
Cellulose F
arbocelbc200
mn-cellulose
solka-flocbw
whatmancc-31
cellulose248
chromediacc31
chromediacf11
pyrocellulose
CELLULOSE D-O
AVICEL PH 102
''AVICEL(R)''
CELLULONFIBER
CELLULOSEDUST
spartoseom-22
HYDROCELLULOSE
CELLULOSEFIBRE
CELLULOSE DS-O
COTTON LINTERS
solka-flocbw20
cupricellulose
solka-flocbw200
solka-flocbw100
CELLULOSE MN100
CELLULOSE DFS-O
ALPHA-CELLULOSE
arbocellb600/30
CELLULOSEFIBRES
Cellulose PEI-F
sulfitecellulose
CELLULOSE POWDER
AVICEL PH 105(R)
AVICEL PH 101(R)
solka-flocbw2030
hydroxycellulose
microcrystalline
PURIFIEDCELLULOSE
CELLULOSE,GEL,FCC
crystal cellulose
Cellulose [50 μm]
Cellulose。Powdered
SOLKAFLOCCELLULOSE
Cellulose powder S
SIGMACELL TYPE 101
CellulosePowderS&S
SPECTROMELT(R) C10
NON-NUTRITIVE BULK
Powdered Cellulose
sigmacell cellulose
INSULATIONCELLULOSE
cellulosecrystalline
Cellulose microcryst
CELLULOSE(PAPERFIBER)
ALPHACEL NON-NUTRITIVE
CELLULOSE POWDER DFS-0
SIGMACELL(R) CELLULOSE
CELLULOSE ION EXCHANGER
CELLULOSE FIBROUS, LONG
CELLULOSE MICROGRANULAR
NATIVE FIBROUS CELLULOSE
CELLULOSE FIBROUS, MEDIUM
Microcrystaline Cellulose
MICROCRYSTALLINE CELLULOSE
CELLULOSE MICROCRYSTALLINE
Cellulose powder S natural
microcrystallineorpowdered
Cellulose Powder S & S 123$
ALPHACEL NON-NUTRITIVE BULK
CELLULOSE POWDER D-0, FOR TLC
CELLULOSEINSULATIONTHERMOLITE
Powdered Cellulose (1 g) (AS)
Microcrystalline Cellulose, NF
Cellulose microcrystalline 102
CELLULOSE, MICROCRYSTALLINE NF
Microcryctaline Cellulose(MCC)
CelluloseMicrocrystalineForTlc
CELLULOSE POWDER DS-0, FOR TLC
α-CELLULOSE NON-NUTRITIVE BULK
TOTAL SUSPENDED SOLID STANDARD
Microcrystalline Cellulose (AS)
CELLULOSE, POWDER, CA. 20 MICRON
Cellulose (pure) respirable dust
MICROCRYSTALLINE CELLULOSE CP2000
CELLULOSE MICROCRYSTALLINE,AVICEL
SIGMACELL MICROCRYSTALLINE TYPE 50
SIGMACELL MICROCRYSTALLINE TYPE 20
CELLULOSE, MICROCRYSTALLINE, POWDER
Cellulose powder, Cotton linters
CELLULOSE,PARTIALLYDEPOLYMERIZED,NF
MICROCRYSTALLINE CELLULOSE 101, 102
HYCIL 101 MICROCRYSTALLINE CELLULOSE
HYCIL 102 MICROCRYSTALLINE CELLULOSE
MICROCRYSTALLINE CELLULOSE USP24/101
MICROCRYSTALLINE CELLULOSE USP24/102
Microcrystalline Cellulose (1 g) (AS)
A-CELLULOSE INSECT CELL CULTURE TESTED
Cellulose microcrystalline ca. 0.020 mm
Cellulose microcrystalline ca. 0.050 mm
Cellulose microcrystalline ca. 0.100 mm
CELLULOSE POWDER DF NATURAL FOR TLC WI&
CELLULOSE POWDER D HIGHLY PURE FOR THIN&
CELLULOSE POWDER D NATURAL FOR THIN-LAY&
CELLULOSE MICROCRYSTALLINE FOR THIN-LAYE
Cellulose (paper fiber) (pure) total dust
Cellulose,Cellulose powder, Cotton linters
Cellulose Microcrystalline, powder, 20 MuM
CELLIONIC BCW 400 - Cellulose solution
CELLULOSE POWDER, FOR COLUMN CHROMATOGRAPHY
CELLIONIC BCW 1100 - Cellulose solution
MICROCRYSTALLINECELLULOSE,MICROCRYSTALLINE,NF
Cellulose powder, Cellulose, Cotton linters
MICROCRYSTALLINE CELLULOSE POWDER (101-102-200)
CELLULOSE HYPHAN(R), H(+)-FORM, MICRO-CR YSTALLINE
CELLULOSE POWDER, FOR COLUMN CHROMAT., A CID WASHED
CELLULOSE MICROCRYSTALLINECA.0.019 MM RESEARCH GRADE
Cellulose microcrystalline ca 0.02mm, research grade
CELLULOSE MICROCRYSTALLINECA. 0.050 MM RESEARCH GRADE
Cellulose microcrystalline, average particle size 50μm
Cellulose Microcrystalline, average particle size 50áM
Cellulose Microcrystalline, average particle size 50 2
Microcrystalline Cellulose, Partially DepolyMerized, NF
Avicel PH 101 Microcrystalline / Cellulose Sodium PH101
Cellulose Microcrystalline, average particle size 50 1KG
Cellulose microcrystalline for thin-layer chromatography
CELLULOSE POWDER FROM SPRUCE, FOR COLUMN CHROMATOGRAPHY
CELLULOSE POWDER, SPRUCE, FOR COLUMN CHR OM., ACID WASHED
Cellulose powder
Cotton linters
Cellulose microcrystalline
Sigmacell Cellulose,Cellulose powder, Cellulose, Cotton linters
Cellulose microcrystalline,extra pure,averageparticle size 90μm
Cellulose microcrystalline, average particle size 90μm, extra pure
Cellulose Microcrystalline, extra pure, average particle size 90áM
Cellulose Microcrystalline, average particle size 90, extra pure 1KG
Cellulose Microcrystalline, average particle size 90, extra pure 250GR
47003, Microcrystalline cellulose (water content above saturated solutions)
Cellulose microcrystalline, Cellulose powder, Cellulose, Cotton linters
Avicel PH-101,Cellulose microcrystalline, Cellulose powder, Cellulose, Cotton linters
Cellulose microcrystalline, Cellulose powder, Cellulose, Cellulosum microcristallinum, Cotton linters | [EINECS(EC#)]
232-674-9 | [Molecular Formula]
H2 | [MDL Number]
MFCD00081512 | [MOL File]
9004-34-6.mol | [Molecular Weight]
2.01588 |
| Chemical Properties | Back Directory | [Definition]
A natural carbohydrate high polymer (polysaccha-
ride) consisting of anhydroglucose units joined by
an oxygen linkage to form long molecular chains
that are essentially linear. It can be hydrolyzed to
glucose. The degree of polymerization is from 1000
for wood pulp to 3500 for cotton fiber, giving a
molecular weight from 160,000 to 560,000.
Cellulose is a colorless solid, d approximately 1.50,
insoluble in water and organic solvents. It will
swell in sodium hydroxide solution and is soluble
in Schweitzer’s reagent. It is the fundamental con-
stituent of all vegetable tissues (wood, grass, cotton,
etc.) and the most abundant organic material in the
world. Cotton fibers are almost pure cellulose; wood
contains approximately 50%.
The physical structure of cellulose is unusual in that it
is not a single crystal but consists of crystalline areas
embedded in amorphous areas. Chemical reagents
penetrate the latter more easily than the former. Cel-
lulose is virtually odorless and tasteless and is com-
bustible, with an ignition point of approximately
450F. In some forms, it is flammable. For example,
railroad shipping regulations require a flammable
label on such items as burnt fiber, burnt cotton,
wet waste paper, and wet textiles. Fires have been
known to occur in warehouses in which telephone
books were stored. These were undoubtedly due to heat buildup in the paper caused by microbial
activity and self-sustaining oxidation.
| [Appearance]
white powder | [Melting point ]
76-78 °C(Solv: acetone (67-64-1); chloroform (67-66-3)) | [density ]
1.5 g/cm3 (20℃) | [refractive index ]
n20/D 1.504 | [Fp ]
164 °C | [storage temp. ]
room temp | [solubility ]
insoluble | [form ]
powder
| [color ]
White or almost white | [Odor]
Odorless | [PH]
5-7.5 (100g/l, H2O, 20℃)(slurry) | [Stability:]
Stable. Combustible. Incompatible with strong oxidizing agents. | [Water Solubility ]
insoluble | [Merck ]
14,1965 | [Dielectric constant]
3.2（Ambient） | [Exposure limits]
ACGIH: TWA 10 mg/m3
OSHA: TWA 15 mg/m3; TWA 5 mg/m3
NIOSH: TWA 10 mg/m3; TWA 5 mg/m3; TWA 1 mg/m3 | [InChIKey]
UFHFLCQGNIYNRP-UHFFFAOYSA-N | [Uses]
Microcrystalline Cellulose is a gum that is the nonfibrous form of cellulose, an alpha-cellulose. It is dispersible in water but not soluble, requiring considerable energy to disperse and hydrate. In this form it is used in dry applications such as tableting, capsules, and shredded cheese where it functions as a non-nutritive filler, binder, flow aid, and anticaking agent. By the addition of carboxymethylcellulose to the alpha-cellulose prior to drying, improved functional properties of hydration and dispersion are obtained. This product is designed for use in water dispersions, being insoluble in water but dispersing in water to form colloidal sols below 1% and white opaque gels above the 1% usage level. It is used as a heat shock stabilizer and bodying agent in frozen desserts, as an opacifier in low-fat dressings, as a foam stabilizer in whipped toppings, and as an emulsifier in dressings. Also termed cellulose gel. | [EPA Substance Registry System]
Cellulose(9004-34-6) |
| Hazard Information | Back Directory | [Chemical Properties]
white powder | [Uses]
ACCEL-101 is most widely used for direct compression tableting and wet granulation.
ACCEL-102 has similar compression properties to ACCEL-101. However, it has larger particle size and therefore, may be of value in improving the flow if fine powders.
ACCEL | [Uses]
High purity cellulose powders for partition chromatography. | [General Description]
Odorless, white powdery fibers. Density 1.5 g cm-3. The biopolymer composing the cell wall of vegetable tissues. Prepared by treating cotton with an organic solvent to de-wax Cellulose microcrystalline and removing pectic acids by extration with a solution of sodium hydroxide. The principal fiber composing the cell wall of vegetable tissues (wood, cotton, flax, grass, etc.). Technical uses depend on the strength and flexibility of its fibers. Insoluble in water. Soluble with chemical degradation in sulfuric aicd, and in concentrated solutions of zinc chloride. Soluble in aqueous solutions of cupric ammonium hydroxide (Cu(NH3)4(OH)2). | [Reactivity Profile]
Cellulose microcrystalline is combustible. Incompatible with strong oxidizing agents including bromine pentafluoride, sodium nitrate, fluorine, perchlorates, perchloric acid, sodium chlorate, magnesium perchlorate, F2, zinc permanganate, sodium nitrite, sodium nitrate, sodium peroxide. Nitration with a mixture of nitric and sulfuric acids produces Cellulose microcrystalline nitrates (celluloid pyroxylin, soluble pyroxyline, guncotton) which are flammable or explosive. | [Occurrence]
The fiber in typical paper can be called “cellulosic”, meaning that cellulose is its most prominent component. Cellulose is present not only in wood, but also in various non-woody plants, such as straw, sugarcane (bagasse), reeds, and hemp. | [Production Methods]
Microcrystalline cellulose and carboxymethylcellulose sodium is a
spray- or bulk-dried blend of microcrystalline cellulose and sodium
carboxymethylcellulose. It is prepared by the chemical depolymerization
of highly purified wood pulp. The original crystalline areas
of the pulp fibers are combined with sodium carboxymethylcellulose,
which serves as a protective colloid and also facilitates
dispersion of the product; it is then either spray- or bulk-dried. | [Production Methods]
Microcrystalline cellulose is manufactured by controlled hydrolysis
with dilute mineral acid solutions of α-cellulose, obtained as a pulp
from fibrous plant materials. Following hydrolysis, the hydrocellulose
is purified by filtration and the aqueous slurry is spraydried
to form dry, porous particles of a broad size distribution. | [Health Hazard]
Cellulose is inert and is classified
as a nuisance dust.
It has little, if any, adverse effect on the
lung, and there are no reports of organic
disease or toxic effect. The health effects
attributed to wood, cotton, flax, jute, and hemp
are not attributable to their cellulose content
but rather to the presence of other substances.
Cellulose fibers were found in the blood
and urine of human volunteers fed dyed cellulose;
there were no ill effects. | [Pharmaceutical Applications]
Microcrystalline cellulose and carboxymethylcellulose sodium is
used to produce thixotropic gels suitable as suspending vehicles in
pharmaceutical and cosmetic formulations. The sodium carboxymethylcellulose
aids dispersion and serves as a protective colloid.
Concentrations of less than 1% solids produce fluid dispersions,
while concentrations of more than 1.2% solids produce thixotropic
gels. When properly dispersed, it imparts emulsion stability, opacity
and suspension in a variety of products, and is used in nasal sprays,
topical sprays and lotions, oral suspensions, emulsions, creams
and gels. | [Industrial uses]
Cellulose is the main constituent of the structureof plants (natural polymer) that, whenextracted, is employed for making paper,plastics, and in many combinations. Celluloseis made up of long-chain molecules inwhich the complex unit C6H10O5 is repeatedas many as 2000 times. It consists of glucose molecules with three hydroxyl groups foreach glucose unit.
One of the simplest forms of cellulose usedindustrially is regenerated cellulose, in whichthe chemical composition of the finished productis similar to that of the original cellulose. Itis made from wood or cotton pulp digested ina caustic solution. Cellophane is a regeneratedcellulose in thin sheets for wrapping and otherspecial uses include windings on wire andcable. | [Biochem/physiol Actions]
Cellulose helps in maintaining the structural stability of plant cell walls. It is an important component of paper and fabrics made from cotton, and linen. | [Safety]
Microcrystalline cellulose is widely used in oral pharmaceutical
formulations and food products and is generally regarded as a
relatively nontoxic and nonirritant material.
Microcrystalline cellulose is not absorbed systemically following
oral administration and thus has little toxic potential. Consumption
of large quantities of cellulose may have a laxative effect, although
this is unlikely to be a problem when cellulose is used as an excipient
in pharmaceutical formulations.
Deliberate abuse of formulations containing cellulose, either by
inhalation or by injection, has resulted in the formation of cellulose
granulomas. | [storage]
Microcrystalline cellulose and carboxymethylcellulose sodium is
hygroscopic and should not be exposed to moisture. It is stable over
a pH range of 3.5–11. Store in a cool, dry place. Avoid exposure to
excessive heat. | [Incompatibilities]
Microcrystalline cellulose is incompatible with strong oxidizing
agents. | [Regulatory Status]
Microcrystalline cellulose and carboxymethylcellulose sodium is a mixture of two materials both of which are generally regarded as nontoxic:
Microcrystalline cellulose GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (inhalations; oral capsules, powders, suspensions, syrups, and tablets; topical and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Carboxymethylcellulose sodium GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental preparations; intra-articular, intrabursal, intradermal, intralesional, and intrasynovial injections; oral drops, solutions, suspensions, syrups and tablets; topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients. |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
37 | [Safety Statements ]
24/25 | [WGK Germany ]
3
| [RTECS ]
FJ5950200
| [F ]
3 | [Autoignition Temperature]
232 °C | [TSCA ]
Yes | [HS Code ]
39129090 | [Safety Profile]
A nuisance dust. When
heated to decomposition it emits acrid
smoke and irritating fumes. | [Toxicity]
LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg |
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