| Identification | More | [Name]
2,5-Di-tert-butylhydroquinone | [CAS]
88-58-4 | [Synonyms]
1,4-DIHYDROXY-2,5-DI-TERT-BUTYLBENZENE
2,5-BIS(2-METHYL-2-PROPYL)-1,4-BENZENEDIOL
2,5-DI-(T-BUTYL)-1,4-BENZOHYDROQUINONE
2,5-DI-(T-BUTYL)-1,4-HYDROQUINONE
2,5-DI-T-BUTYLHYDROQUINONE
2,5-DI(TERT-BUTYL)-1,4-BENZENEDIOL
2,5-DI-TERT-BUTYL-1,4-HYDROQUINONE
2,5-DI-TERT-BUTYLHYDROQUINONE
2,5-DI-TERT-BUTYL HYDROXYQUINONE
2,5-ditertiary butyl hydroquinone
BHQ
BUTYLHYDROQUINONE-TERT
DBHQ
Dibutylhydroquinone
DI-T-BUTYLHYDROQUINONE
DI-TERT-BUTYL HYDROQUINONE(2,5-)
TBUBHQ
T-BUTYLATED HYDROQUINONE
1,4-Benzenediol,2,5-bis(1,1-dimethylethyl)-
2,5-bis(1,1-dimethylethyl)-4-benzenediol | [EINECS(EC#)]
201-841-8 | [Molecular Formula]
C14H22O2 | [MDL Number]
MFCD00008825 | [Molecular Weight]
222.32 | [MOL File]
88-58-4.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
MX5160000
| [Autoignition Temperature]
790 °F | [Hazard Note ]
Irritant | [TSCA ]
Yes | [HS Code ]
29072900 |
| Hazard Information | Back Directory | [Description]
2,5-Di-tert-butylhydroquinone, also known as 2,5-TBHQ or DTBHQ, belongs to the class of organic compounds known as phenylpropanes. These are organic compounds containing a phenylpropane moiety. It is a phenol derivative containing 2 phenol groups and 2 alkyl groups, each consisting of three methyl groups. | [Chemical Properties]
cream or pale brown solid | [Uses]
2,5-Di-tert-butylhydroquinone is the oxidation substrate used to measure the catalytic activity of the copper(II) enzyme-like catalysts. | [Definition]
ChEBI: A member of the class of hydroquinones that is benzene-1,4-diol substituted by tert-butyl groups at position 2 and 5. | [General Description]
Mobilizes Ca2+ specifically from the Ins(1,4,5)P3-sensitive Ca2+ stores by inhibiting microsomal and sarcoplasmic reticulum Ca2+-ATPase activity. Does not affect mitochondrial Ca2+ fluxes or plasma membrane Ca2+/Mg2+ ATPase activity. Useful for the study of endomembrane Ca2+ stores and plasma membrane Ca2+ permeability pathways. | [Biological Activity]
A selective inhibitor of endoplasmic reticulum Ca 2+ -ATPase. | [Biochem/physiol Actions]
2,5-Di-tert-butylhydroquinone specifically inhibits the sarcoplasmic reticulum (SR) Ca2+ uptake in the rat ventricle. | [Purification Methods]
Crystallise the hydroquinone from *C6H6 or AcOH. [Beilstein 6 III 4741.] | [References]
[1]. hasséssian h, vaca l, kunze dl. blockade of the inward rectifier potassium current by the ca(2+)-atpase inhibitor 2',5'-di(tert-butyl)-1,4-benzohydroquinone (bhq). br j pharmacol, 1994, 112(4): 1118-1122.
[2]. fusi f, gorelli b, valoti m, et al. effects of 2,5-di-t-butyl-1,4-benzohydroquinone (bhq) on rat aorta smooth muscle. eur j pharmacol, 1998, 346(2-3): 237-243.
[3]. fusi f, saponara s, gagov h, et al. 2,5-di-t-butyl-1,4-benzohydroquinone (bhq) inhibits vascular l-type ca(2+) channel via superoxide anion generation. br j pharmacol, 2001, 133(7): 988-996.
[4]. jan cr, ho cm, wu sn, et al. mechanism of rise and decay of 2,5-di-tert-butylhydroquinone-induced ca2+ signals in madin darby canine kidney cells. eur j pharmacol, 1999, 365(1): 111-117. |
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