| Identification | More | [Name]
4-Aminoantipyrine | [CAS]
83-07-8 | [Synonyms]
1,5-DIMETHYL-2-PHENYL-4-AMINOPYRAZOLONE
1-PHENYL-2,3-DIMETHYL-4-AMINO-3-PYRAZOLIN-5-ON
1-PHENYL-2,3-DIMETHYL-4-AMINOPYRAZOLONE
4-AMINO-1,3-DIMETHYL-2-PHENYL-3-PYRAZOLONE
4-AMINO-1,5-DIMETHYL-2-PHENYL-1,2-DIHYDRO-PYRAZOL-3-ONE
4-AMINO-1,5-DIMETHYL-2-PHENYL-3H-PYRAZOL-3-ONE
4-Amino-1,5-dimethyl-2-phenyl-3-pyrazolone
4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE
4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLINE-5-ONE
4-AMINOANTIPYRENE
4-AMINOANTIPYRIN
4-AMINOANTIPYRINE
4-AMINOANTIPYRINE REAGENT
4-AMINOPHENAZONE
AKOS BBS-00007964
AMINOANTIPYRINE
AMINOANTIPYRINE, 4-
AMINOANTIPYRINE REAGENT
AMINOPHENYZONE
AMPYRONE | [EINECS(EC#)]
201-452-3 | [Molecular Formula]
C11H13N3O | [MDL Number]
MFCD00003145 | [Molecular Weight]
203.24 | [MOL File]
83-07-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Amber crystalline powder | [Melting point ]
105-110 °C(lit.)
| [Boiling point ]
340 C | [density ]
0.8
| [refractive index ]
1.4930 (estimate) | [storage temp. ]
Store at RT. | [solubility ]
H2O: 0.1 g/mL, clear
| [form ]
Powder or Crystals | [pka]
pK1: 4.94(+1) (25°C) | [color ]
Yellow to yellow-brown | [Odor]
Odorless | [PH]
7.1 (100g/l, H2O, 20℃)(slurry) | [Stability:]
Stable. May be light sensitive. | [Water Solubility ]
ca. 500 g/L (20 ºC) | [Merck ]
14,591 | [BRN ]
181635 | [LogP]
-0.257 (est) | [CAS DataBase Reference]
83-07-8(CAS DataBase Reference) | [NIST Chemistry Reference]
Aminoantipyrene(83-07-8) | [Storage Precautions]
Light sensitive | [EPA Substance Registry System]
83-07-8(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3
| [RTECS ]
CD2480000
| [F ]
8-9-23 | [Hazard Note ]
Harmful | [TSCA ]
Yes | [HS Code ]
29331190 | [Toxicity]
LD50 orally in Rabbit: 1700 mg/kg |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Sulfuric acid-->Sodium nitrite-->Ammonium bisulfite-->Antipyrine-->Starch paper-->2,3-dimethyl-4-nitroso-1-phenyl-3-pyrazolin-5-one | [Preparation Products]
Aminopyrine-->1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-3H-pyrazol-3-one-->AMMONIUM ALGINATE-->N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)formamide-->Ramifenazone-->N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3-methoxybenzamide-->2-CYANO-N-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-ACETAMIDE-->3-CHLORO-N-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)PROPANAMIDE-->AMINOPROPYLON |
| Hazard Information | Back Directory | [Chemical Properties]
Amber crystalline powder | [Application]
4-aminoantipyrine is the most widely used analytical reagent for the estimation of phenol. It is used as a reagent for glucose determination in the presence of peroxidase and phenol. It is also used as indicator for trace phenol determinations in water.
Phenolic compounds were determined by buffering the sample to a pH of 10.0 and adding 4-aminoantipyrine to produce a yellow or amber colored complex in the presence of ferricyanide ion. The colour is intensified through extraction of the complex into chloroform. Measurement of this colour quantitatively determines the phenol concentration of the sample. | [Uses]
4-Aminoantipyrine is a metabolite of aminopyrine, having both analgesic and anti-inflammatory properties.
Coupling Reagent for Trinder’s reagents in colorimetric hydrogen peroxide detectionassays
Forms highly stable dyes by coupling with Trinder’s reagents in presence of Peroxidase and H2O2. Therefore suitable for use in test strip and solution diagnostics.
| [Uses]
A reagent for glucose determination in the presence of peroxidase and phenol | [Uses]
Indicator for trace phenol determinations in water. | [Definition]
ChEBI: A pyrazolone, a member of the class of pyrazoles that is antipyrine substituted at C-4 by an amino group. It is a metabolite of aminopyrine and of metamizole. | [Preparation]
synthesis of 4-aminoantipyrine: Antipyrine is nitrosated by sodium nitrite, reduced by ammonium bisulfite and ammonium sulfite, hydrolyzed by sulfuric acid, and finally neutralized with liquid ammonia to obtain 4-aminoantipyrine. | [General Description]
4-Aminoantipyrine forms heterocyclic Schiff bases, by reaction with various aldehydes and oximes. These Schiff bases form stable complexes with transition metals. | [Purification Methods]
It crystallises from EtOH or EtOH/ether. [Beilstein 25 III/IV 3554.] |
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