| Identification | More | [Name]
Aluminium phosphate | [CAS]
7784-30-7 | [Synonyms]
ALUMINIUM PHOSPHATE
ALUMINIUM PHOSPHATE BASIC
ALUMINUM O-PHOSPHATE
ALUMINUM ORTHOPHOSPHATE
ALUMINUM PHOSPHATE
ALUMINUM PHOSPHATE TRIBASIC
aluminiumphosphat
aluminiumphosphate,tribasic
aluminophosphoricacid
aluminumacidphosphate
aluminummonophosphate
aluminumphosphate(1:1)
aluminumphosphate(non-specificname)
aluminumphosphate,solution
aluphos
ffb32
monoaluminumphosphate
phosphalugel
Phosphoricacid,aluminumsalt(1:1)
aluminium orthophosphate | [EINECS(EC#)]
232-056-9 | [Molecular Formula]
AlO4P | [MDL Number]
MFCD00003430 | [Molecular Weight]
121.95 | [MOL File]
7784-30-7.mol |
| Chemical Properties | Back Directory | [Appearance]
Aluminum orthophosphate is a white crystalline solid which is often used in liquid or gel form | [Melting point ]
1500 °C | [density ]
2.56 g/mL at 25 °C(lit.)
| [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Very slightly soluble in water, practically insoluble in alcohol. It dissolves in dilute solutions of mineral acids and alkali hydroxides. | [form ]
Powder | [color ]
White | [Specific Gravity]
2.566 | [Water Solubility ]
Insoluble | [Merck ]
14,358 | [Solubility Product Constant (Ksp)]
pKsp: 20.01 | [Dielectric constant]
6.0（Ambient） | [Exposure limits]
ACGIH: TWA 1 mg/m3 | [InChI]
InChI=1S/Al.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+3;/p-3 | [InChIKey]
ILRRQNADMUWWFW-UHFFFAOYSA-K | [SMILES]
[Al+3].P([O-])([O-])([O-])=O | [CAS DataBase Reference]
7784-30-7(CAS DataBase Reference) | [EPA Substance Registry System]
7784-30-7(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3260 8/PG 2
| [WGK Germany ]
1
| [RTECS ]
TB6450000
| [TSCA ]
Yes | [HazardClass ]
8 | [HS Code ]
28352990 | [Safety Profile]
Corrosive to the eyes, skin, and mucous membranes. When heated to decomposition it emits toxic fumes of POx. Used as an antacid and as a cement component, flux for ceramics, dental cement, glass, and gels. See also ALUMINUM COMPOUNDS and PHOSPHATES | [Toxicity]
LD50 oral in mouse: > 5gm/kg |
| Hazard Information | Back Directory | [General Description]
A colorless liquid. Insoluble in water. Corrosive to metals and tissue. | [Reactivity Profile]
An acid. The resulting aqueous solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions. | [Air & Water Reactions]
Insoluble in water. | [Health Hazard]
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. | [Potential Exposure]
Used as a flux in ceramics; in dental cements; in the manufacture of special glasses, paints and varnishes, cosmetics; making pulp and paper; as an antacid.
| [Fire Hazard]
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. | [First aid]
Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.
| [Shipping]
UN1760 Corrosive liquids, n.o.s., Hazard class: 8; Labels: 8-Corrosive material, Technical Name Required. UN3260 Corrosive solid, acidic, inorganic, n.o.s., Hazard class: 8; Labels: 8-Corrosive material, Technical Name Required. | [Incompatibilities]
A strong oxidizer; keep away from combustible materials. Violent reaction with reducing agents; strong bases. Material is an inorganic acid and will react, possibly violently, with bases; corrosive to metals, some plastics and body tissues | [Chemical Properties]
Aluminum orthophosphate is a white crystalline solid which is often used in liquid or gel form | [Chemical Properties]
Aluminum phosphate adjuvant is a white hydrogel that sediments
slowly and forms a clear supernatant. | [Chemical Properties]
White or almost white powder. | [Physical properties]
White powdery solid (rhombic plate); the mineral berlinite (AlPO4) has hexagonal quartz-like structure; refractive index 1.546; mp > 1,500°C; density 2.566 g/cu3; insoluble in water and alcohol; Ksp 9.83x10-10 very slightly soluble in HCl or HNO3. | [Occurrence]
The compound occurs in nature as the mineral, berlinite. Also, it occurs in nature in minerals, amblygonite, [NaAl(PO4)(OH)]; augelite, [Al2(PO4)(OH)3]; lazulite, [(Mg,Fe)Al2(PO4)2(OH)2]; variscite [(Al,Fe3+)(PO4)?2H2O]; and wavellite, [Al3(OH)3?(PO4)2?5H2O]. It is used as flux for ceramics; as cement in combination with calcium sulfate and sodium silicate; and in the manufacture of special glasses. It is also used in dried gel and therapeutically as an antacid. | [Uses]
Antacid; vaccine adjuvant | [Uses]
As a flux for ceramics, preparation of dental cement, cement with calcium sulfate and sodium silicate, special glasses, as gel in pharmacy.Aluminum phosphate is used as catalysts, molecular sieves, flux for ceramics and as a gel in pharmacy. It is employed in the preparation of dental cement, emollients and fire-resistant coating. It plays an important role as an anti-fouling agent in textile industry. | [Preparation]
It is prepared by treating sodium aluminate with phosphoric acid. | [Production Methods]
Aluminum phosphate adjuvant is formed by the reaction of a
solution of aluminum chloride and phosphoric acid with alkali
hydroxide. | [Brand name]
Phosphaljel
(Wyeth-Ayerst). | [Hazard]
Solutions are corrosive to tissue. | [Flammability and Explosibility]
Nonflammable | [Pharmaceutical Applications]
Aluminum phosphate adjuvant is used in parenteral human and
veterinary vaccines.It activates Th2 immune responses, including
IgG and IgE antibody responses. | [Clinical Use]
Phalu Gel's main active ingredient is aluminum Phosphorus. Aluminum Phosphate works to reduce excess stomach acid. This gel suspension, when taken to the stomach, will form a protective layer on the surface of the gastrointestinal mucosa, similar to the effect of mucus or mucosal protective factors to help cover the stomach from the impact of fluids. The aluminum phosphate layer in the stomach has a smooth dispersion effect, going to the ulcers in the stomach and making them heal faster, making the patient feel more comfortable and less painful. Aluminum Phosphorus, when used, does not affect the intestinal absorption of Phosphorus. Phalu-Gel will quickly reduce the pain of stomach ulcers and the discomfort of excess acid, help heal the ulcers quickly, and make the patient feel comfortable right away.Aluminum hydroxide, aluminum phosphate, and potassium aluminum sulfate (alum) are used as adjuvants in vaccines designed to stimulate systemic immunity. Aluminum salts are used in DPT, pneumocccal conjugate, hepatitis A, papilloma, anthrax, and rabies vaccines. Like other systemic adjuvants, they form an insoluble depot and slowly release the antigen, which stimulates an antibody response. | [Safety]
Aluminum phosphate adjuvant is intended for use in parenteral
vaccines and is generally regarded as safe. It may cause mild
irritation, dryness, and dermatitis on skin contact. It may also cause
redness, conjunctivitis, and short-term mild irritation on eye
contact. Ingestion of large amounts of aluminum phosphate
adjuvant may cause respiratory irritation with nausea, vomiting,
and constipation. Inhalation is unlikely, although the dried product
may cause respiratory irritation and cough. Type I hypersensitivity
reactions following parenteral administration have also been
reported. | [storage]
Aluminum phosphate adjuvant is stable for at least 2 years when
stored at 4–308℃ in well-sealed inert containers. It must not be
allowed to freeze as the hydrated colloid structure will be
irreversibly damaged. | [Regulatory Status]
GRAS listed. Accepted for use in human and veterinary vaccines in
Europe and the USA. The limits for use in human vaccines are
0.85 mg aluminum/dose (FDA) and 1.25 mg aluminum/dose
(WHO). There are no established limits for use in veterinary
vaccines. Reported in the EPA TSCA Inventory. |
| Questions and Answers (Q&A) | Back Directory | [Description]
Aluminium phosphate occurs in nature as the mineral, berlinite. Also, it occurs in nature in minerals, amblygonite, [NaAl(PO4)(OH)]; augelite, [Al2(PO4)(OH)3]; lazulite, [(Mg,Fe)Al2(PO4)2(OH)2]; variscite [(Al,Fe3+)(PO4)•2H2O]; and wavellite, [Al3(OH)3•(PO4)2•5H2O]. It is used as flux for ceramics; as cement in combination with calcium sulfate and sodium silicate; and in the manufacture of special glasses. It is also used in dried gel and therapeutically as an antacid.
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