| Identification | More | [Name]
2-Aminoimidazole | [CAS]
7720-39-0 | [Synonyms]
1H-IMIDAZOL-2-AMINE
2-AMINOIMIDAZOLE
2-Amino-1H-Imidazole | [EINECS(EC#)]
231-751-4 | [Molecular Formula]
C3H5N3 | [MDL Number]
MFCD00792530 | [Molecular Weight]
83.09 | [MOL File]
7720-39-0.mol |
| Hazard Information | Back Directory | [Uses]
2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of human arginase I with a Ki of 3.6 mM.
| [in vivo]
The 2-aminoimidazole analogs A1P (80 μg/g, Nebulization, Once in total) can reduce airways hyperresponsiveness to methacholine in an acute (3-week) ovalbumin (OVA)-sensitization and -challenge murine model[3]. | Animal Model: | Female Balb/C mice (6 - 8 weeks old) [Acute (3-week) ovalbumin (OVA)-sensitization and -challenge murine model][3] | | Dosage: | 80 μg/g, Once in total | | Administration: | Nebulization | | Result: | The 2-aminoimidazole analogs A1P attenuated significantly the total resistance of the respiratory system (R) and the maximum resistance of the central airways (RN) following methacholine challenge. |
| [storage]
4°C, protect from light |
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