| Identification | More | [Name]
5-Amino-4-imidazolecarboxamide | [CAS]
360-97-4 | [Synonyms]
4(5)-AMINO-5(4)-IMIDAZOLECARBOXAMIDE
4-AMINO-1H-IMIDAZOLE-5-CARBOXAMIDE
4-AMINO-5-IMIDAZOLECARBOXAMIDE
4-AMINOIMIDAZOLE-5-CARBOXAMIDE
5-AMINO-1H-IMIDAZOLE-4-CARBOXAMIDE
5-amino-4-imidazolecarboxamide
5-AMINOIMIDAZOLE-4-CARBOXAMIDE
4-amino-5-imidazolecarboxamid
5-amino-1h-imidazole-4-carboxamid
5-Amino-4-glyoxalinecarboxamide
5-amino-imidazole-4-carboxamid
aic
aminoimidazolecarboxamide
ba2756
diazol-c
1H-Imidazole-4-carboxamide, 5-amino-
5-amino-4-imidazolylcarboxamide
4-Amino-5-imidazolecarboxamide monohydrate
AICA, 4-Amino-5-carbamoylimidazole,
4-Amino-5-imodazole | [EINECS(EC#)]
206-641-4 | [Molecular Formula]
C4H6N4O | [MDL Number]
MFCD02181040 | [Molecular Weight]
126.12 | [MOL File]
360-97-4.mol |
| Chemical Properties | Back Directory | [Appearance]
White to Off-White Solid | [Melting point ]
164-170 °C(lit.)
| [Boiling point ]
234.22°C (rough estimate) | [density ]
1.3659 (rough estimate) | [refractive index ]
1.8500 (estimate) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Powder | [pka]
11.97±0.10(Predicted) | [color ]
White | [Water Solubility ]
Soluble in DMSO, Methanol, Water. | [Usage]
A metabolite of Temozolomide | [InChI]
InChI=1S/C4H6N4O/c5-3-2(4(6)9)7-1-8-3/h1H,5H2,(H2,6,9)(H,7,8) | [InChIKey]
DVNYTAVYBRSTGK-UHFFFAOYSA-N | [SMILES]
C1NC(N)=C(C(N)=O)N=1 | [CAS DataBase Reference]
360-97-4(CAS DataBase Reference) | [EPA Substance Registry System]
360-97-4(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
NI3910000
| [TSCA ]
Yes | [HS Code ]
29332900 |
| Questions And Answer | Back Directory | [Description]
5-Amino-4-imidazolecarboxamide may be used in the synthesis of 4-(N′-benzoylcarbamoyl)amino-5-imidazolecarboxamide and 5-amino-1-β-D-ribosyl-4-imidazolecarboxamide-5′-phosphate (AICAR).It is an imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides. When compounded with orotic acid, it is used to treat liver diseases.
| [Reference]
3. Black, S. L., M. J. Black, and J. H. Mangum. "A rapid assay for 5-amino-4-imidazolecarboxamide ribotide transformylase." Analytical Biochemistry90.1(1978):397-401.
|
| Hazard Information | Back Directory | [Chemical Properties]
White to Off-White Solid | [Uses]
A metabolite of Temozolomide | [Definition]
ChEBI: An aminoimidazole in which the amino group is at C-5 with a carboxamido group at C-4. | [storage]
Store at -20°C |
|
|