| Identification | More | [Name]
2-HYDROXY-5-NITROBENZYL BROMIDE | [CAS]
772-33-8 | [Synonyms]
2-BROMOMETHYL-4-NITROPHENOL
2-HYDROXY-5-NITROBENZYL BROMIDE
ALPHA-BROMO-4-NITRO-2-CRESOL
ALPHA-BROMO-4-NITRO-O-CRESOL
KOSHLAND I
KOSHLAND REAGENT
KOSHLAND'S REAGENT
KOSHLAND'S REAGENT I
2-(bromomethyl)-4-nitro-pheno
o-Cresol, alpha-bromo-4-nitro-
Phenol, 2-(bromomethyl)-4-nitro-
a-Bromo-4-nitro-o-cresol
a-Bromo-4-nitro-o-methylphenol
BETA-1-BROMO-4-NITRO-O-CRESOL
α-bromo-4-nitro-o-cresol
α-Bromo-4-nitro-o-cresol, 2-Bromomethyl-4-nitrophenol, Koshland I, Koshlands Reagent I
2-Hydroxy-5-nitrobenzyl bromide ,95%
Koshland's reagent 1 | [EINECS(EC#)]
212-248-9 | [Molecular Formula]
C7H6BrNO3 | [MDL Number]
MFCD00007340 | [Molecular Weight]
232.03 | [MOL File]
772-33-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Beige to yellow crystalline powder | [Melting point ]
144-149 °C(lit.) | [Boiling point ]
383.0±32.0 °C(Predicted) | [density ]
1.795 | [refractive index ]
1.6090 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
chloroform: soluble25mg/mL, clear, yellow | [form ]
Crystalline Powder | [pka]
6.16±0.30(Predicted) | [color ]
Beige to light brown | [Detection Methods]
HPLC | [BRN ]
1868798 | [CAS DataBase Reference]
772-33-8(CAS DataBase Reference) | [Storage Precautions]
Moisture sensitive | [EPA Substance Registry System]
Phenol, 2-(bromomethyl)-4-nitro- (772-33-8) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3261 8/PG 2
| [WGK Germany ]
3
| [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29089990 |
| Hazard Information | Back Directory | [Chemical Properties]
Beige to yellow crystalline powder | [Uses]
2-Hydroxy-5-nitrobenzyl bromide was used in covalent modification of tryptophan and tryptophan residues in monoclonal immunoglobulin. It was also used as reagent for sulfhydryl modification | [Uses]
2-Hydroxy-5-nitrobenzyl bromide is a chemical reagent that reacts with and modifies chemically the tryptophan portion of protein molecules.. | [Uses]
Reagent for sulfhydryl modification.1 | [Synthesis Reference(s)]
Journal of the American Chemical Society, 86, p. 1448, 1964 DOI: 10.1021/ja01061a045 | [General Description]
2-Hydroxy-5-nitrobenzyl bromide is a protein modifying reagent. | [Purification Methods]
Crystallise the bromide from *benzene or *benzene/ligroin. It is slightly soluble in EtOH, soluble in *C6H6 and AcOH, and very soluble in ligroin. [Beilstein 6 H 367.] |
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