| Identification | More | [Name]
Benzyl bromide | [CAS]
100-39-0 | [Synonyms]
A-BROMOTOLUENE
ALPHA-BROMOPHENYLMETHANE
ALPHA-BROMOTOLUENE
BENZYL BROMIDE
bromomethylbenzene
N-BENZYL BROMIDE
(bromomethyl)-benzen
1-Bromotoluene
ai3-15300
alpha-bromo-toluen
Bromophenylmethane
-Bromotoluene
Bromotoluene, alpha
bromotoluene,alpha
cyclite
omega-Bromotoluene
Toluene, alpha-bromo-
α-bromotoluene
3b-Hydroxy-5A-Androstane-17-ONE
Benzyl bromide/alpha-Bromotoluene | [EINECS(EC#)]
202-847-3 | [Molecular Formula]
C7H7Br | [MDL Number]
MFCD00000172 | [Molecular Weight]
171.03 | [MOL File]
100-39-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Benzylbromide is a combustible, colorless
to yellow liquid with a pleasant odor. Molecular | [Melting point ]
-3 °C | [Boiling point ]
198-199 °C(lit.)
| [density ]
1.44 g/mL at 20 °C
| [vapor density ]
5.8 (vs air)
| [vapor pressure ]
0.5 hPa (20 °C) | [refractive index ]
n20/D 1.575(lit.)
| [Fp ]
188 °F
| [storage temp. ]
Store at RT. | [solubility ]
Miscible with benzene, carbon tetrachloride, ethanol and ether. | [form ]
Liquid | [color ]
Clear colorless to yellow | [Odor]
Very sharp, pungent, like tear gas. | [Stability:]
Stable. Combustible. Incompatible with strong oxidizing agents. | [Sensitive ]
Moisture Sensitive/Light Sensitive | [Detection Methods]
GC,NMR | [Merck ]
14,1128 | [BRN ]
385801 | [Dielectric constant]
5.1（20℃） | [InChIKey]
AGEZXYOZHKGVCM-UHFFFAOYSA-N | [Uses]
Making foaming and frothing agents, organic synthesis. | [CAS DataBase Reference]
100-39-0(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzene, (bromomethyl)-(100-39-0) | [Storage Precautions]
Light sensitive;Moisture sensitive | [EPA Substance Registry System]
100-39-0(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S39:Wear eye/face protection .
S2:Keep out of the reach of children . | [RIDADR ]
UN 1737 6.1/PG 2
| [WGK Germany ]
2
| [RTECS ]
XS7965000
| [F ]
9-19-21 | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
II | [HS Code ]
29039900 | [Hazardous Substances Data]
100-39-0(Hazardous Substances Data) | [Toxicity]
dns-esc 1300 mmol/L ZKKOBW 92,177,78 |
| Hazard Information | Back Directory | [General Description]
A colorless liquid with an agreeable odor. Toxic by inhalation and by skin absorption. BENZYL BROMIDE(100-39-0) is slightly soluble in water and denser than water (density 1.44 g/cm3 (Aldrich)). A lachrymator. Corrosive to metals and tissue. | [Reactivity Profile]
BENZYL BROMIDE reacts with water, alcohols, common metals (except nickel and lead), bases, amines and oxidizing agents. . This material stored over activated 4A molecular sieve burst a bottle due to condensation-polymerization reaction with generation of HBr gas, [Chem. Eng. News, 1979, 57(12), 74]. | [Air & Water Reactions]
Sensitive to exposure to light and moisture. Slightly soluble in water. | [Hazard]
Highly toxic. Corrosive to skin and tissue. A lachrymator. | [Health Hazard]
Inhalation causes irritation of nose and throat; severe exposure may cause pulmonary edema. Vapors cause severe eye irritation; liquid can burn eyes. Skin contact causes irritation. Ingestion causes irritation of mouth and stomach. | [Potential Exposure]
It is used as a chemical intermediate;
in organic syntheses; as a foaming and frothing agent. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, including
resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medical
attention. If victim is conscious, administer water or
milk. Do not induce vomiting. Medical observation is
recommended for 24 to 48 hours after breathing overexposure,
as pulmonary edema may be delayed. As first aid for
pulmonary edema, a doctor or authorized paramedic may
consider administering a drug or other inhalation therapy. | [Shipping]
UN1737 Benzyl Bromide, Hazard class: 6.1;
Labels: 6.1—Poisonous materials, 8—Corrosive material. | [Incompatibilities]
May form explosive mixture with air.
Contact with water forms hydrogen bromide and benzyl
alcohol. Incompatible with strong oxidizers, bases, magnesium.
Attacks metals, except nickel and lead, in the
presence of moisture. | [Description]
Benzyl bromide is a combustible, colorless toyellow liquid with a pleasant odor. Molecularweight=171.05;Specific gravity (H2O:1) =1.438; Boilingpoint= 198℃; Freezing/Melting point =-4.0℃;Flashpoint =79℃ (cc). Hazard Identification (based on NFPA-704 M Rating System): Health 3, Flammability 2,Reactivity 1. Insoluble in water (slowly decomposes). | [Chemical Properties]
Benzylbromide is a combustible, colorless
to yellow liquid with a pleasant odor. Molecular | [Chemical Properties]
Clear light amber liquid | [Waste Disposal]
Pour into vermiculite, sodium
bicarbonate, or a sand-soda ash mixture and transfer to
paper boxes, then to an open incinerator. Alternatively, mix
Benzyl Bromide 417
with flammable solvent and spray into incinerator equipped
with after burner and alkali scrubber. | [Application]
Benzyl bromide is an aromatic halide that is mainly used as a protecting agent for protecting hydroxy group of alcohols via O-benzylation reaction. It has been used as an initiator in the synthesis of poly(styrene-b-methylmethacrylate) copolymers by atom transfer radical polymerization. It can undergo Menschutkin reaction with 1, 2-dimethylimidazole to form 3-benzyl-1, 2-dimethylimidazolium bromide.? | [Definition]
ChEBI: A member of the class of benzyl bromides that is toluene substituted on the alpha-carbon with bromine. | [Preparation]
Benzyl bromide is synthesized by toluene bromination. Toluene heated to 50°C, add bromine reaction, the reaction temperature of 75-80°C, reaction 6h, fractional distillation at atmospheric pressure to remove the fraction before 140°C, and then distillation under reduced pressure, collect 112-114°C(2.0kPa) fraction, to get benzyl bromide. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 95, p. 3412, 1973 DOI: 10.1021/ja00791a072
Tetrahedron Letters, 29, p. 707, 1988 DOI: 10.1016/S0040-4039(00)80190-2
The Journal of Organic Chemistry, 51, p. 929, 1986 DOI: 10.1021/jo00356a032 | [Chemical Reactivity]
Reactivity with Water Reacts slowly generating hydrogen bromide (hydrobromic acid); Reactivity with Common Materials: Decomposes rapidly in the presence of all common metals except nickel and lead, liberating heat and hydrogen bromide; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Rinse with sodium bicarbonate or lime solution; Polymerization: Polymerizes with evolution of heat and hydrogen bromide when in presence with all common metals except nickel and lead; Inhibitor of Polymerization: None. | [Safety Profile]
Intensely irritating and corrosiveto skin, eyes, and mucous membranes. Large doses causecentral nervous system depression. Mutation datareported. Reaction with molecular sieve produces toxichydrogen bromide gas. | [storage]
Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Color Code—White: Corrosiveor Contact Hazard; Store separately in a corrosion-resistantlocation. Store in tightly closed containers in a cool, wellventilated area away from water and other incompatiblematerials listed above. | [Purification Methods]
Wash benzyl chloride with conc H2SO4 (CARE), water, 10% Na2CO3 or NaHCO3 solution, and again with water. Dry it with CaCl2, Na2CO3 or MgSO4 and fractionally distil it in the dark, under reduced pressure. It has also been thoroughly degassed at 10-6 mm and redistilled in the dark. This gives material with max (MeCN): 226nm ( 8200) [Mohammed & Kosower J Am Chem Soc 93 2709 1971]. [Beilstein 5 IV 829.] Handle in a fume cupboard, extremely LACHRYMATORY. |
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