| Identification | More | [Name]
DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID | [CAS]
76326-31-3 | [Synonyms]
APV
AP-5
DL-AP5
DL-APV
C13734
(±)-2-AP5
5-phosphono-L-norvaline
Norvaline, 5-phosphono-
5-PHOSPHONO-DL-NORVALINE
2-amino-5-phosphopentanoicacid
2-amino-5-phosphonopentanoicaci
DL-2-AMINO-5-PHOSPHONOVALERIC ACID
DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID
(S)-2-Amino-5-phosphonopentanoic acid
(+/-)-Amino-5-phosphono-pentanoic acid
DL-2-Amino-5-phosphonovaleric acid (AP5)
(+/-)-2-AMINO-5-PHOSPHONO-PENTANOIC ACID
DL-2-AMINO-5-PHOSPHONOVALERIC ACID (DL-AP5)
rac-(2R*)-2-Amino-5-phosphonopentanoic acid
DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID (DL-AP5)
5-Phosphono-DL-norvaline, DL-2-Amino-5-phosphonovaleric acid, AP-5, APV | [Molecular Formula]
C5H12NO5P | [MDL Number]
MFCD00010515 | [Molecular Weight]
197.13 | [MOL File]
76326-31-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
238-245oC | [Boiling point ]
482.1±55.0 °C(Predicted) | [density ]
1.529±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
NH4OH 1 M: 50 mg/mL, clear, colorless
| [form ]
solid
| [pka]
2.46±0.10(Predicted) | [color ]
white
| [Water Solubility ]
Soluble to 10 mM in water and to 100 mM in 1eq. NaOH | [BRN ]
2446389 | [CAS DataBase Reference]
76326-31-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [F ]
10 |
| Hazard Information | Back Directory | [Uses]
DL-2-Amino-5-phosphonopentanoic acid has been used:
- in the inactivation of N-methyl-D-aspartate (NMDA)-mediated synapses
- used in growth medium for inhibition of electrical activity in the neuronal network
- used to isolate N-methyl-D-aspartate receptors (NMDAR) or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated currents were isolated using this product
- used in double distilled water to compare its NMDA antagonistic action with that of prion protein (PrPC)
| [Definition]
ChEBI: The 5-phosphono derivative of 2-aminopentanoic acid; acts as an N-methyl-D-aspartate receptor antagonist. | [Biological Activity]
Potent NMDA antagonist. See separate isomers (D-(-)-2-Amino-5-phosphonopentanoic acid and L-(+)-2-Amino-5-phosphonopentanoic acid ). | [Biochem/physiol Actions]
Anticonvulsant; potent and selective NMDA receptor antagonist. | [storage]
Store at -20°C |
|
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