| Identification | Back Directory | [Name]
Methyl 1-Cbz-azetidine-3-carboxylate | [CAS]
757239-60-4 | [Synonyms]
Methyl 1-Cbz-azetidine-3-...
Methyl 1-Cbz-azetidine-3-carboxylate
1-benzyl 3-Methyl azetidine-1,3-dicarboxylate
1-Cbz-3-azetidinecarboxylic acid Methyl ester
1-CBZ-AZETIDINE-3-CARBOXYLIC ACID METHYL ESTER
O1-benzyl O3-methyl azetidine-1,3-dicarboxylate
Methyl 1-benzyloxycarbonylazetidine-3-carboxylate
1-benzyloxycarbonyl-3-azetidinecarboxylic acid methyl ester
1-Benzyloxycarbonyl-3-azetidinecarboxylic acid methyl ester 97%
azetidine-1,3-dicarboxylic acid O3-methyl ester O1-(phenylmethyl) ester | [Molecular Formula]
C13H15NO4 | [MDL Number]
MFCD11110708 | [MOL File]
757239-60-4.mol | [Molecular Weight]
249.264 |
| Hazard Information | Back Directory | [Uses]
Methyl 1-Cbz-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Cbz-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1 | [IC 50]
Non-cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
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| Company Name: |
Energy Chemical
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021-021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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