| Identification | More | [Name]
2-Hydroxy-2-methylpropiophenone | [CAS]
7473-98-5 | [Synonyms]
2-BENZOYL-2-PROPANOL
2-HYDROXY-2-METHYL-1-PHENYL-1-PROPANONE
2-HYDROXY-2-METHYL-1-PHENYL PROPANONE
2-HYDROXY-2-METHYL-PHENYLPROPANE-1-ONE
2-HYDROXY-2-METHYLPROPIOPHENONE
HYDROXYMETHYL PROPIOPHENONE
1-Phenyl-2-hydroxy-2-methylpropan-1-one
2-hydroxy-2-methyl-1-phenyl-1-propanon
a-Hyd[cl]roxyMethy1[e]propiophenone
photoinitiator1173
alpha-Hydroxyisobutyrophenone
BENZOYL ISOPROPANOL
Photocure-1173
1-Phenyl-2-Hydroxy-2-Methyl-1-Propanone
2-Hydroxy-2-Methylpheny-Propane-1-one
1-Propanone, 2-hydroxy-2-methyl-1-phenyl-
ACETOCURE 73
2,2-DIMETHYL-α-HYDROXYACETOPHENONE
IHT-PI 1173
Globalchem Globalcure-73 | [EINECS(EC#)]
231-272-0 | [Molecular Formula]
C10H12O2 | [MDL Number]
MFCD00040710 | [Molecular Weight]
164.2 | [MOL File]
7473-98-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
4°C | [Boiling point ]
102-103 °C4 mm Hg(lit.)
| [density ]
1.077 g/mL at 25 °C(lit.)
| [vapor pressure ]
0.57Pa at 20℃ | [refractive index ]
n20/D 1.533(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Practically insoluble in water | [form ]
clear liquid | [pka]
13.23±0.29(Predicted) | [color ]
Colorless to Light orange to Yellow | [Specific Gravity]
1.077 | [Odor]
Slight odor | [Water Solubility ]
13.3g/L at 20℃ | [InChIKey]
XMLYCEVDHLAQEL-UHFFFAOYSA-N | [LogP]
1.62 at 25℃ | [CAS DataBase Reference]
7473-98-5(CAS DataBase Reference) | [EPA Substance Registry System]
7473-98-5(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
3082 | [WGK Germany ]
3
| [RTECS ]
UC2977245
| [HazardClass ]
9 | [PackingGroup ]
III | [HS Code ]
29144000 |
| Hazard Information | Back Directory | [Hazard]
Moderately toxic by ingestion. | [Chemical Properties]
Yellowish clear liquid | [Synthesis Reference(s)]
Tetrahedron Letters, 29, p. 4365, 1988 DOI: 10.1016/S0040-4039(00)80496-7 | [General Description]
2-Hydroxy-2-methylpropiophenone is a radical photoinitiator (PI) molecule that can be used in the crosslinking of polymers by the exposure of UV radiation. It can be used in the development of UV curable resins for exterior coating applications. | [Flammability and Explosibility]
Notclassified | [Synthesis]
KBr in water is added to a solution of 2-methyl-1-phenylpropane-1,2-diol in toluene. Then, TEMPO is added. The reddish suspension is cooled to 0°C. A 12 % sodium hypochlorite solution is added while maintaining the internal temperature at 5°C or lower. The mixture is stirred for 1 h at 0-5°C and then separated for 10 min. Sodium dithionite solution (obtained from 30 g sodium dithionite (85%) and 400 ml of water)is added to the organic phase and stirred at 85°C for 1-2 h. The organic phase is again separated and concentrated (rotavap). The crude product is then subjected to fractional distillation, yielding 2-Hydroxy-2-methylpropiophenone as a colorless oil.
 | [Toxics Screening Level]
The ITSL for 2-hydroxy-2-methyl-1-phenyl-1-propanone has been changed from 0.04 μg/m3 to 0.1 μg/m3 based on annual averaging time. |
| Questions And Answer | Back Directory | [Uses]
2-Hydroxy-2-methylpropiophenone is a photoinitiator.In addition, 2-hydroxy-2-methylpropiophenone is an important organic intermediate (building block) to synthetize substituted propiophenone products.
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