| Identification | More | [Name]
Triethylamine trihydrofluoride | [CAS]
73602-61-6 | [Synonyms]
HF
HF 37% IN TRIETHYLAMINE
HYDROGEN FLUORIDE TRIETHYLAMINE
MEC-82
TRIETHYLAMINE TRIHYDROFLUORIDE
TRIETHYLAMINE TRISHYDROFLUORIDE
TRIETHYLAMINE TRIS(HYDROGEN FLUORIDE)
Triethylamin-trihydrofluoride
TriethylamineX3Hf
Hydrogen fluoride in triethylamine
Ethanamine, N,N-diethyl-, trihydrofluoride
Triethylamine trihydrofluoride 97%
Triethylaminetrihydrofluoride97%
HYDROGEN FLUORIDE IN TRIETHYLAMINE: TECH.
TRIETHYLAMINE TRIHYDROFLUORIDE: CA 37% HF
N,N-Diethylethanamine trihydrofluoride
Triethylamine·3hydridefluorine salt
Triethylamine·3hydrogen fluoride
Triethylamine·trihydrofluoric acid | [EINECS(EC#)]
277-550-5 | [Molecular Formula]
C6H18F3N | [MDL Number]
MFCD00043294 | [Molecular Weight]
161.21 | [MOL File]
73602-61-6.mol |
| Chemical Properties | Back Directory | [Appearance]
clear yellow liquid | [Melting point ]
-29--27°C | [Boiling point ]
70 °C15 mm Hg(lit.)
| [density ]
0.989 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.3915(lit.)
| [Fp ]
190 °F
| [storage temp. ]
Keep Cold | [solubility ]
soluble in Chloroform, Hexane | [form ]
Liquid | [color ]
Clear yellow to brown | [Specific Gravity]
0.989 | [PH]
3 (H2O, 20℃)(saturated aqueous solution) | [Water Solubility ]
soluble | [Sensitive ]
Hygroscopic | [BRN ]
5522945 | [Exposure limits]
ACGIH: TWA 2.5 mg/m3
NIOSH: IDLH 250 mg/m3 | [CAS DataBase Reference]
73602-61-6(CAS DataBase Reference) | [EPA Substance Registry System]
73602-61-6(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T+,T,C,Xi | [Risk Statements ]
R26/27/28:Very Toxic by inhalation, in contact with skin and if swallowed .
R35:Causes severe burns.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S7/9:Keep container tightly closed and in a well-ventilated place .
S36/37:Wear suitable protective clothing and gloves .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 3265 8/PG 2
| [WGK Germany ]
3 | [Hazard Note ]
Corrosive | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29211910 |
| Questions And Answer | Back Directory | [Application]
The t-butyldimethylsilyl (TBDMS) group is the most widely used 2'-OH protection in synthesis of oligoribonucleotides. The TBDMS-group became much used particularly after it was combined with phosphoroamidite methodology and was also the choice when H-phosphonate based RNA-synthesis was introduced. Removal of TBDMS-protection is most commonly done with 1 M tetrabutylammonium fluoride (TBAF) in tetrahydrofuran (THF). These conditions has proven efficient.
|
| Hazard Information | Back Directory | [Chemical Properties]
clear yellow liquid | [Uses]
Triethylamine trihydrofluoride acts as a mild and selective fluorinating agent used in the synthesis of acid fluorides and alkyl fluorides. It is also used in the synthesis of vicinal difluorides from epoxides, 3-fluoroazetidine. It is utilized as a selective reagent for the cleavage of O-silyl groups in carbohydrates, nucleotides and cyanohydrins. It is actively involved in the electrochemical fluorodeiodination of alkyl iodides and fluorodesilylation in beta-lactams. | [General Description]
Triethylamine trihydrofluoride (TREAT-HF) is a mild and selective reagent for the fluorination of a wide variety of compounds. |
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