| Identification | Back Directory | [Name]
Atractylenolide-1 | [CAS]
73069-13-3 | [Synonyms]
Atracylenolide I
ATRACTYLENOLIDE-1
Atractylenolide Ⅰ
8,9-Dehydroasterolide
Atractylenolide I, >99%
Eudesma-4(15),7(11),8-trien-12-olide
3,8aβ-Dimethyl-5-methylene-2,4,4aα,5,6,7,8,8a-octahydronaphtho[2,3-b]furan-2-one
(4aS,8aS)-4a,5,6,7,8,8a-Hexahydro-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one
Naphtho[2,3-b]furan-2(4H)-one,4a,5,6,7,8,8a-hexahydro-3,8a-dimethyl-5-methylene-, (4aS,8aS)- | [Molecular Formula]
C15H18O2 | [MDL Number]
MFCD09037395 | [MOL File]
73069-13-3.mol | [Molecular Weight]
230.3 |
| Chemical Properties | Back Directory | [Melting point ]
121-123 °C(Solv: ligroine (8032-32-4)) | [Boiling point ]
405.0±44.0 °C(Predicted) | [density ]
1.12 | [Fp ]
170℃ | [storage temp. ]
2-8°C | [solubility ]
methanol: soluble1mg/mL, clear, colorless | [InChIKey]
ZTVSGQPHMUYCRS-SWLSCSKDSA-N |
| Hazard Information | Back Directory | [Description]
Atractylenolide I is a sesquiterpene that has been found in the rhizomes of A. macrocephala and has diverse biological activities, including anti-inflammatory, anti-angiogenic, anti-tumor, and antidepressant properties.1,2,3,4 It inhibits LPS-induced increases in TNF-α and nitric oxide (NO) production, as well as inducible nitric oxide synthase (iNOS) activity, in murine peritoneal macrophages (IC50s = 23.1, 41, and 67.3 μM, respectively).1 Atractylenolide I reduces pouch fluid weight, inflammatory cell count, granuloma weight, and vascular index (ID50s = 24.18, 19.46, 14.44, and 15.15 mg/kg, respectively) in a mouse air pouch granuloma model induced by Freund''s complete adjuvant (FCA).2 It also reduces the number of microvessels in the air pouch wall by 58.27% when administered at a dose of 20 mg/kg and reduces the blood levels of TNF-α, IL-1β, IL-6, VEGF, placenta growth factor (PlGF), and bFGF in a dose-dependent manner in a mouse model of FCA-induced granuloma. Atractylenolide I inhibits the growth of T-24, 5637, RT4, and 253J bladder cancer cells in vitro (IC50s = 12.8-63.7 μM) and reduces tumor growth in T-24 and 253J mouse xenograft models in a dose-dependent manner.3 In a mouse model of depression induced by chronic unpredictable mild stress, atractylenolide I reverses stress-induced decreases in hippocampal levels of serotonin (5-HT; Item No. 14332) and norepinephrine (Item No. 16673) and reduces immobility time in the forced swim and tail suspension tests in a dose-dependent manner, indicating antidepressant-like activity.4 |
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