| Identification | More | [Name]
Amodiaquin dihydrochloride dihydrate | [CAS]
6398-98-7 | [Synonyms]
4-[(7-CHLORO-4-QUINOLINYL)AMINO]-2-[(DIETHYLAMINO)METHYL]PHENOL DIHYDROCHLORIDE
4-([7-chloro-4-quinolinyl]amino)-2-([diethylamino]methyl)phenol dihydrochloride dihydrate
4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol dihydrochloride
7-chloro-4-(3'-diethylaminomethyl-4'-hydroxyanilino)quinoline dihydrochloride
acrichin dihydrochloride
AMODIAQUIN DIHYDROCHLORIDE
amodiaquin dihydrochloride dihydrate
AMODIAQUINE DIHYDROCHLORIDE
AMODIAQUINE HCL
AMODIAQUINE HYDROCHLORIDE
AMODIAQUIN HYDROCHLORIDE
Amodiaquine hydrochloride USP24
AMODIAQUINE 2HCL DIHYDRATE
AMODIAQUINE DIHYDROCHLORIDE 2-HYDRATE
AMODIAQUIN DIHYDROCHLORIDE DIHYDATE | [EINECS(EC#)]
200-706-0 | [Molecular Formula]
C20H24Cl3N3O | [MDL Number]
MFCD00078857 | [Molecular Weight]
428.78 | [MOL File]
6398-98-7.mol |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow powder | [Uses]
An anti-malarial quinoline derivative that acts as an histamine N-methyltransferase inhibitor | [Uses]
antimalarial | [Brand name]
Camoquin (Parke-Davis). | [Biological Activity]
Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent. | [in vivo]
In vivo administration of a small dose amodiaquine dramatically enhanced the effect of histamine on the gastric secretion in dogs. Amodiaquine prevents severe hepatic injury and high lethality in P. acnes-primed and LPS-induced hepatitis mice. Its treatment enhances the elevation of histamine in the liver of P. acnes-primed and LPS-induced hepatitis mice without accompanying tele-methyl histamine elevation. |
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