| Identification | More | [Name]
D-(+)-Maltose monohydrate | [CAS]
6363-53-7 | [Synonyms]
4-O-A-D-GLUCOPYRANOSYL-D-GLUCOSE
4-O-ALPHA-D-GLUCOPYRANOSYL-D-GLUCOPYRANOSE
4-O-ALPHA-D-GLUCOPYRANOSYL-D-GLUCOPYRANOSE MONOHYDRATE
4-O-ALPHA-D-GLUCOPYRANOSYL-D-GLUCOSE MONOHYDRATE
4-O-ALPHA-G-GLUCOPYRANOSYL-D-GLUCOSE
D-MALATOSE
D-MALTOSE
D-MALTOSE, H2 O
D-(+)-MALTOSE HYDRATE
D(+)-MALTOSE MONOHYDRATE
D-MALTOSE MONOHYDRATE
MALATOSE, D-
MALTOBIOSE
MALTOBIOSE MONOHYDRATE
MALTOSE
MALTOSE H2O
MALTOSE MONOHYDRATE
MALT SUGAR
MALT SUGAR MONOHYDRATE
D-Glucose, 4-O-alpha-D-glucopyranosyl-, monohydrate | [EINECS(EC#)]
200-716-5 | [Molecular Formula]
C12H24O12 | [MDL Number]
MFCD00149343 | [Molecular Weight]
360.31 | [MOL File]
6363-53-7.mol |
| Chemical Properties | Back Directory | [Appearance]
White crystalline powder | [Melting point ]
119-121 °C (dec.)(lit.)
| [alpha ]
137 º (c=4, H2O, NH3) | [storage temp. ]
Store at RT. | [solubility ]
H2O: 50 mg/mL
| [form ]
powder
| [color ]
White | [PH]
5.0-7.0 (25℃, 0.5M in H2O) | [optical activity]
[α]20/D +130±2°, 24 hr, c = 4% in H2O | [Water Solubility ]
1080 g/L (20 ºc) | [λmax]
λ: 260 nm Amax: 0.08
λ: 280 nm Amax: 0.07 | [Merck ]
14,5714 | [BRN ]
5784659 | [CAS DataBase Reference]
6363-53-7(CAS DataBase Reference) | [NIST Chemistry Reference]
«beta»-Maltose monohydrate(6363-53-7) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R33:Danger of cumulative effects.
R63:Possible risk of harm to the unborn child.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [RTECS ]
OO5250000 | [F ]
3 | [TSCA ]
Yes | [HS Code ]
17029000 |
| Hazard Information | Back Directory | [Chemical Properties]
Maltose occurs as white crystals or as a crystalline powder. It is
odorless and has a sweet taste approximately 30% that of sucrose. | [Chemical Properties]
White crystalline powder | [Uses]
A disaccharide commonly found in foods and commonly utilized in brewing processes. | [Production Methods]
Maltose monohydrate is prepared by the enzymatic degradation of
starch. | [General Description]
Maltose monohydrate is commonly used as a tablet filler or excipient in pharmaceutical industry.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. | [Pharmaceutical Applications]
Maltose is a disaccharide carbohydrate widely used in foods and
pharmaceuticals. In parenteral products, maltose may be used as a
source of sugar, particularly for diabetic patients.
Crystalline maltose is used as a direct-compression tablet
excipient in chewable and nonchewable tablets. | [Biochem/physiol Actions]
Maltose is a disaccharide containing two glucose molecules with an α(1→4) glycosidic linkage. Maltose can be derived from starch in food through the action of amylase. Maltose can be found in many food products, including beer, cereals, and pasta. | [Safety]
Maltose is used in oral and parenteral pharmaceutical formulations
and is generally regarded as an essentially nontoxic and nonirritant
material. However, there has been a single report of a liver
transplantation patient with renal failure who developed hyponatremia
following intravenous infusion of normal immunoglobulin
in 10% maltose. The effect, which recurred on each of four
successive infusions, resembled that of hyperglycemia and was
thought to be due to accumulation of maltose and other osmotically
active metabolites in the extracellular fluid.
LD50 (mouse, IV): 26.8 g/kg
LD50 (mouse, SC): 38.6 g/kg
LD50 (rabbit, IV): 25.2 g/kg
LD50 (rat, IP): 30.6 g/kg
LD50 (rat, IV): 15.3 g/kg
LD50 (rat, oral): 34.8 g/kg | [storage]
Maltose should be stored in a well-closed container in a cool, dry
place. | [Purification Methods]
Purify maltose by chromatography from aqueous solution on to a charcoal/Celite (1:1) column, wash it with water to remove glucose and other monosaccharides, then elute it with aqueous 75% EtOH. Crystallise it from water, aqueous EtOH or EtOH containing 1% nitric acid. Dry it as the monohydrate at room temperature under vacuum over H2SO4 or P2O5. Also purify it by dissolving it in MeOH, evaporating to a syrup which on standing for 12hours in contact with 1/10th its volume of H2O gives crystals of the monohydrate. Its iodine number is 55.5. The osazone has m 200o(dec) and [] D 20 +58o (c 1.4, H2O). [Howarth et al. J Chem Soc 793 1937, Beilstein 17 III/IV 3057, 17 V 189.] | [Incompatibilities]
Maltose may react with oxidizing agents. A Maillard-type reaction
may occur between maltose and compounds with a primary amine
group, e.g. glycine, to form brown-colored products. | [Regulatory Status]
In the USA, maltose is considered as a food by the FDA and is
therefore not subject to food additive and GRAS regulations.
Included in the FDA Inactive Ingredients Database (oral solutions).
Included in the Canadian List of Acceptable Non-medicinal
Ingredients. Included in parenteral products available in a number
of countries worldwide. |
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