| Identification | More | [Name]
Wogonin | [CAS]
632-85-9 | [Synonyms]
5,7-dihydroxy-8-methoxy-2-phenyl-4h-1-benzopyran-4-one
5,7-DIHYDROXY-8-METHOXYFLAVON
5,7-DIHYDROXY-8-METHOXYFLAVONE
WOGONIN
5,7-dihydroxy-8-methoxy-2-phenyl-4h-1-benzopyran-4-on
vogonin
WOGONIN 98.0% BY HPLC
WOOGONIN
WOGONIN hplc
WILDYAMP.E
4H-1-Benzopyran-4-one,5,7-dihydroxy-8-methoxy-2-phenyl-
2-Phenyl-5,7-dihydroxy-8-methoxy-4H-1-benzopyran-4-one | [EINECS(EC#)]
1592732-453-0 | [Molecular Formula]
C16H12O5 | [MDL Number]
MFCD00017736 | [Molecular Weight]
284.26 | [MOL File]
632-85-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
203-206°C | [Boiling point ]
518.8±50.0 °C(Predicted) | [density ]
1.420±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMSO: ≥20mg/mL | [form ]
Yellow solid | [pka]
6.83±0.40(Predicted) | [color ]
Light Yellow to Yellow | [λmax]
319nm(EtOH)(lit.) | [InChIKey]
XLTFNNCXVBYBSX-UHFFFAOYSA-N | [LogP]
2.140 (est) | [CAS DataBase Reference]
632-85-9(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
Wogonin acts as an anti-inflammatory agent, attenuating ovalbumin antigen-influenced neutrophillic airway inflammation. In addition, it reverses multi-drug resistance of human myelogenous leukemia. | [Definition]
ChEBI: A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8. | [General Description]
Wogonin is a flavonoid component of Scutellaria baicalensis Georgi roots. | [Biochem/physiol Actions]
Wogonin is an anti-inflammatory agent and COX-2 inhibitor, which inhibits the induction of both iNOS and COX-2. Wogonin inhibits COX-2 (IC50 = 46 μM) without affecting COX-1. Wogonin inhibits iNOS induction and thus inhibts activation-induced C6 glial cell death. Specifically, Wogonin inhibits NF-kappaB-mediated iNOS induction. | [storage]
Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
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