| Identification | More | [Name]
CIS-ACONITIC ANHYDRIDE | [CAS]
6318-55-4 | [Synonyms]
CIS-ACONITIC ACID ANHYDRIDE
CIS-ACONITIC ANHYDRIDE
CIS-PROPENE-1,2,3-TRICARBOXYLIC ACID ANHYDRIDE
CIS-PROPENE-1,2,3-TRICARBOXYLIC ANHYDRIDE
2,5-dihydro-2,5-dioxo-3-furanaceticaci
2,5-dihydro-2,5-dioxofuran-3-acetic acid
Cis-AconiticAnhydride98%
aconitic anhydride
cis-ACONITIC ANHYDRIDE extrapure for biochemistry
(2,5-Dioxo-3-furyl)acetic acid
2,5-Dihydro-2,5-dioxo-3-furanacetic acid
2,5-Dioxo-2,5-dihydrofuran-3-acetic acid | [EINECS(EC#)]
228-663-3 | [Molecular Formula]
C6H4O5 | [MDL Number]
MFCD00005524 | [Molecular Weight]
156.09 | [MOL File]
6318-55-4.mol |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3261 8/PG 2
| [WGK Germany ]
3
| [F ]
10-21 | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
III |
| Hazard Information | Back Directory | [Uses]
cis-Aconitic anhydride is used in the preparation of poly(amino acid)-containing copolymers with gradient pH-sensitive side groups initiated by the amino groups in methoxy poly(ethylene glycol)-block-poly(L-lysine). It is also involved in the preparation of pH-sensitive anti-tumor prodrug nanoparticles by conjugation with D-alfa-tocopheryl polyethylene glycol 1000 succinate (TPGS). | [Purification Methods]
Reflux it in xylene (7.5 parts) for 1hour, then evaporate and recrystallise the residue from *C6H6. Alternatively, reflux it in Ac2O, evaporate and recrystallise from *C6H6. It is sensitive to moisture. [IR: Groth & Dahlén Acta Chem Scand 21 291 1967, Malachowski & Maslowski Chem Ber 61 2523 1928, NMR: Gawron & Mahajan Biochemistry 5 2335 1966.] [Beilstein 18/8 V 530.] |
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