| Identification | More | [Name]
2,5-Dibromopyridine | [CAS]
624-28-2 | [Synonyms]
2,5-DIBROMOPYRIDINE
PYRIDINE, 2,5-DIBROMO-
Dibromopyridine
2,5-Dibromopyridine, 97+%
2,5-dibromopyridin
2,5-DIBROMOPYRIDINE 2,5-DIBROMOPYRIDINE
2,5-Dibromo pyridine ,98% | [EINECS(EC#)]
210-839-6 | [Molecular Formula]
C5H3Br2N | [MDL Number]
MFCD00006221 | [Molecular Weight]
236.89 | [MOL File]
624-28-2.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-White Crystals | [Melting point ]
92-95 °C (lit.) | [Boiling point ]
235 °C / 772mmHg | [density ]
2.0383 (rough estimate) | [refractive index ]
1.5800 (estimate) | [Fp ]
62℃ | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Crystalline Powder | [pka]
-1.57±0.10(Predicted) | [color ]
Almost white or light beige to brown | [Water Solubility ]
insoluble | [Detection Methods]
GC,NMR,HPLC | [BRN ]
109099 | [CAS DataBase Reference]
624-28-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S36:Wear suitable protective clothing . | [RIDADR ]
UN2811 | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29333999 |
| Hazard Information | Back Directory | [Chemical Properties]
2,5-Dibromopyridine is an off-white crystalline solid. It is insoluble in water but soluble in strong polar organic solvents. It exhibits strong alkalinity.
| [Uses]
2,5-Dibromopyridine (cas# 624-28-2) is a compound useful in organic synthesis. | [Preparation]
To synthesize 2,5-dibromopyridine, follow these steps:
Add 2-amino-5-bromopyridine (13.0 kg) into a water-cooled solution at 10 °C.
Slowly add 47% aqueous hydrogen bromide (37 L) to the mixture.
Introduce liquid bromine (11 L) into the mixture.
Maintain the reaction temperature below 10 °C.
Prepare a solution of NaNO2 (16.1 kg) and H2O (19 L) and add it dropwise to the mixture while keeping the temperature between 0-5 °C.
Stir the reaction mixture for 30 minutes.
Treat the mixture with a solution of NaOH (28.0 kg) in water (30 L) at a controlled rate below 20-25 °C.
Extract the reaction mixture with diethyl ether (3 × 40 L).
Dry the organic layer with anhydrous Na2SO4.
Remove the desiccant by filtration.
Evaporate the resulting filtrate under reduced pressure to dryness.
Suspend the residue in heptane (10 L).
Collect the target product molecule, 2,5-dibromopyridine, by filtration.
Synthesis method of 2,5-dibromopyridine |
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