| Identification | Back Directory | [Name]
GSK-3BETA INHIBITOR XII | [CAS]
601514-19-6 | [Synonyms]
TWS11
TWS S
TWS119
CS-445
CS-1924
TWS119, >=98%
TWS-119; TWS 119
OTAVA-BB 7070707013
GSK-3BETA INHIBITOR XII
GSK-3β Inhibitor, TWS119
GSK-3β Inhibitor XII, TWS119
GSK-3BETA INHIBITOR XII USP/EP/BP
TWS 119 (This product is unavailable in the U.S.)
3-[6-(3-AMINO-PHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YLOXY]-PHENOL
Phenol, 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-
TWS 119 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxyphenolditrifluoroacetate
3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol TWS 119 | [Molecular Formula]
C18H14N4O2 | [MDL Number]
MFCD09037535 | [MOL File]
601514-19-6.mol | [Molecular Weight]
318.335 |
| Chemical Properties | Back Directory | [Melting point ]
249 °C | [density ]
1.42 | [storage temp. ]
Desiccate at +4°C | [solubility ]
insoluble in H2O; insoluble in EtOH; ≥15.9 mg/mL in DMSO | [form ]
powder | [pka]
8.99±0.10(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
Acts as an ARMS-selective inihibitor, through GSK3 (Glucose Synthase Kinase 3) inhibition. | [Definition]
ChEBI: 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol is a member of pyrroles. | [General Description]
A cell-permeable and potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM), leading to an increase in the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 μM) and embryonic stem cells (D3; 50-60% at 400 nM). | [Biological Activity]
Inhibitor of glycogen synthase kinase-3 β (IC 50 = 30 nM). Induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs). | [Biochem/physiol Actions]
TWS119 favors the γδT cells survival and proliferation by activating the mammalian target of rapamycin (mTOR) pathway. It also promotes the expression of T-cell factor 1 (TCF1) and modulates cytokine production. | [target]
GSK-3β | [storage]
Store at -20°C | [References]
[1] ding s, wu t y h, brinker a, et al. synthetic small molecules that control stem cell fate. proceedings of the national academy of sciences, 2003, 100(13): 7632-7637.
[2] wu t y h, ding s. applying chemical tools to the discovery of novel regenerative medicine. drug discovery today: technologies, 2006, 3(3): 255-260. |
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