| Identification | More | [Name]
Butorphanol tartrate | [CAS]
58786-99-5 | [Synonyms]
1-N-CYCLOBUTYLMETHYL-3,14-DIHYDROXYMORPHINAN TARTRATE SALT
BUTORPHANOL TARTRATE
BUTORPHANOL TARTRATE SALT
l-n-cyclobutylmethyl-3,14-dihydroxymorphinan tartrate salt
MORPHINAN-3,14-DIOL, 17-(CYCLOBUTYLMETHYL)-, (S-(R*,R*))-2,3-DIHYDROXYBUTANEDIOATE (1:1) (SALT)
MORPHINAN-3,14-DIOL, 17-(CYCLOBUTYLMETHYL)-,(S-(R,R))-2,3-DIHYDROXYBUTANEDIOATE (1:1) (SALT)
morphinan-3,14-diol,17-(cyclobutylmethyl)-,(s-(r*,r*))-2,3-dihydroxybutanedi
oate(1:1)(salt)
stadol
torate
torbutrol
butorphanol tartrate---dea schedule iv
17-(cyclobutylmethyl)morphinan-3,14-diyl [S-(R*,R*)]-2,3-dihydroxysuccinate
Morphinan-3,14-diol, 17-(cyclobutylmethyl)-, (2S,3S)-2,3-dihydroxybutanedioate (1:1) (salt)
BUTORPHANOLTARTRATE,USP
l-Butorphanol tartrate
Levo-BC 2627 tartrate
Moradol
NIH 10275
Torbugesic | [EINECS(EC#)]
261-443-5 | [Molecular Formula]
C25H35NO8 | [MDL Number]
MFCD00214257 | [Molecular Weight]
477.55 | [MOL File]
58786-99-5.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R63:Possible risk of harm to the unborn child. | [Safety Statements ]
S22:Do not breathe dust .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
1544 | [WGK Germany ]
3
| [RTECS ]
QC7795000
| [HazardClass ]
6.1(a) | [PackingGroup ]
II | [HS Code ]
2933492250 | [Toxicity]
LD50 in mice, rats (mg/kg): 40-57, 17-20 i.v.; 395-527, 570-756 orally (Heel) |
| Hazard Information | Back Directory | [Description]
Butorphanol (tartrate) (Item No. 23812) is an analytical reference material categorized as an opioid.1 Butorphanol is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications. | [Uses]
Analgesic;
antitussive. | [Definition]
ChEBI: The (S,S)-tartaric acid salt of butorphanol. It is used for relief or moderate to severe pain. | [Brand name]
Stadol (Bristol-Myers Squibb). | [Biochem/physiol Actions]
κ/μ opioid receptor agonist. | [Mechanism of action]
Butorphanol is a strong agonist at κ opioid receptors, and through this interaction, it is five times
more potent than morphine as an analgesic. The κagonists have a lower ceiling analgesic effect
than full μ agonists; thus, they are not as effective in treating severe pain. Butorphanol is an
antagonist at μ opioid receptors with approximately one-sixth the potency of naloxone. If given to a
person addicted to a μ agonist, butorphanol will induce an immediate onset of abstinence
syndrome. | [Side effects]
Butorphanol has a different spectrum of side effects than μ opioid analgesics. Respiratory
depression occurs. There is a lower ceiling on this effect, however, and it is not generally lethal,
as is the case with high doses of μ agonists. Major side effects after normal analgesic doses are
sedation, nausea, and sweating, as well as dysphoric (hallucinogenic) effects at higher doses.
Butorphanol causes an increase in pulmonary arterial pressure and pulmonary vascular resistance.
There is an overall increased workload on the heart, and it should not be used in patients with
congestive heart failure or to treat pain from acute myocardial infarction. Butorphanol has low abuse potential and is not a scheduled drug. | [Veterinary Drugs and Treatments]
Approved indication for dogs is “. . . for the relief of chronic nonproductive
cough associated with tracheobronchitis, tracheitis,
tonsillitis, laryngitis and pharyngitis originating from inflammatory
conditions of the upper respiratory tract” (Package Insert;
Torbutrol?—Fort Dodge). It is also used in practice in both dogs and
cats as a preanesthetic medication, analgesic, and as an antiemetic
prior to cisplatin treatment (although not very effective in cats for
this indication). Compared with other opiate analgesics, butorphanol
is not very useful in small animals (particularly dogs) for treating
pain and has to be dosed frequently.
The approved indication for horses is “. . . for the relief of pain
associated with colic in adult horses and yearlings” (Package Insert;
Torbugesic?—Fort Dodge). It has also been used clinically as an analgesic
in cattle. |
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