| Identification | More | [Name]
Histamine dihydrochloride | [CAS]
56-92-8 | [Synonyms]
1H-IMIDAZOLE-4-ETHANAMINE DIHYDROCHLORIDE
2-(1H-IMIDAZOL-4-YL)-ETHYLAMINE 2HCL
2-(1H-IMIDAZOL-4-YL)ETHYLAMINE DIHYDROCHLORIDE
2-[4-IMIDAZOLYL]-ETHYLAMINE 2HCL
2-(4-IMIDAZOLYL)ETHYLAMINE DIHYDROCHLORIDE
2-[4-IMIDAZOYL]-ETHYLAMINE DIHYDROCHLORIDE
HISTAMINE 2HCL
HISTAMINE DIHCL
HISTAMINE DIHYDROCHLORIDE
HISTAMINI DIHYDROCHLORIDUM
TIMTEC-BB SBB003722
bichlorhydrated’histamine
edihydrochlorideAvailablefrom1kgto100kg.
histaminedichloride
OCHLORIDE
2-imidazol-4-ylethylamine dihydrochloride
HISTAMINE DICHLORHYDRATE
Histamine-alpha,alpha,??d4?HCl)2
HISTAMINE DIHYDROCHLORIDE, PH EUR
HISTAMINE DIHYDROCHLORIDE (1H-IMIDAZOLE-4-ETHAN | [EINECS(EC#)]
200-298-4 | [Molecular Formula]
C5H11Cl2N3 | [MDL Number]
MFCD00012703 | [Molecular Weight]
184.07 | [MOL File]
56-92-8.mol |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Melting point ]
249-252 °C(lit.)
| [storage temp. ]
2-8°C
| [solubility ]
H2O: 0.1 g/mL, clear, colorless
| [form ]
powder
| [color ]
white to off-white
| [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
SOLUBLE | [Detection Methods]
T,NMR | [Merck ]
14,4719 | [BRN ]
3624116 | [InChIKey]
PPZMYIBUHIPZOS-UHFFFAOYSA-N | [CAS DataBase Reference]
56-92-8(CAS DataBase Reference) | [EPA Substance Registry System]
56-92-8(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R42/43:May cause sensitization by inhalation and skin contact .
R42:May cause sensitization by inhalation.
R22:Harmful if swallowed. | [Safety Statements ]
S22:Do not breathe dust .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S37:Wear suitable gloves .
S36/37:Wear suitable protective clothing and gloves . | [RIDADR ]
3335 | [WGK Germany ]
2
| [RTECS ]
MS1575000
| [F ]
1-8-9 | [Hazard Note ]
Irritant | [TSCA ]
Yes | [HazardClass ]
IRRITANT | [HS Code ]
29332900 |
| Hazard Information | Back Directory | [Chemical Properties]
white powder | [Uses]
Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor. It is a potent vasodilator and endogenous histamine receptor agonist. | [Uses]
Present in most mammalian tissues; primarily stored in mast cells and basophils. Exhibits multiple biological effects through at least 3 specific receptors. Induces bronchoconstriction and vasodilation; stimulates gastric acid secretion; and acts as a neurotransmitter. | [General Description]
Histamine Dihydrochloride is a derivative of histamine, which is implicated in tumor cell apoptosis and prevents the relapse of acute myeloid leukemia in patients. It prevents the formation of ROS (reactive oxygen species) and inhibits the activation of T cells and natural killer cells.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. | [Biological Activity]
Endogenous agonist at histamine receptors (H 1-4 ). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo . | [Biochem/physiol Actions]
Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor. | [storage]
Room temperature (desiccate) | [Purification Methods]
The dihydrochloride crystallises from aqueous EtOH. The phosphate (2H3PO4) [51-74-1] has m 132-133o (from H2O). [Beilstein 25 III/IV 2049.] |
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