| Identification | More | [Name]
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one | [CAS]
55314-16-4 | [Synonyms]
1-(3-PYRIDYL)-3-(DIMETHYLAMINO)-2-PROPEN-1-ONE
3-(DIMETHYLAMINO)-1-(3-PYRIDINYL)-2-PROPEN-1-ONE
3-(Dimethylamino)-1-pyridin-3-ylprop-2-en-1-one
1-(3-PYRIDYL)-3-(DIMETHYLAMINO)-2-PROPEN-1-ONE 95%
2-propen-1-one,3-（dimethylamino）-1-（3-pyridinyl）
3-Dimethylamino-1-(pyridin-3-yl)propenone
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one ,97% | [EINECS(EC#)]
1533716-785-6 | [Molecular Formula]
C10H12N2O | [MDL Number]
MFCD00115180 | [Molecular Weight]
176.22 | [MOL File]
55314-16-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-White Solid | [Melting point ]
86-88 | [Boiling point ]
281.4±36.0 °C(Predicted) | [density ]
1.070±0.06 g/cm3(Predicted) | [vapor pressure ]
0.049Pa at 20℃ | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Soluble in chloroform and dichloromethane. | [form ]
powder to crystal | [pka]
6.19±0.70(Predicted) | [color ]
Light yellow to Brown | [Usage]
Imatinib intermediate | [Detection Methods]
HPLC | [InChI]
InChI=1S/C10H12N2O/c1-12(2)7-5-10(13)9-4-3-6-11-8-9/h3-8H,1-2H3 | [InChIKey]
MZLRFUCMBQWLNV-FNORWQNLSA-N | [SMILES]
C(C1=CC=CN=C1)(=O)C=CN(C)C | [LogP]
0.26 at 20℃ and pH7.2 | [Surface tension]
71.8mN/m at 1.008g/L and 20℃ | [CAS DataBase Reference]
55314-16-4(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one can be used in the synthesis of imatinib and nilotinib (AMN107), a compound currently in multiple Phase II/III clinical trials for chronic granulocytic leukaemia. Imatinib, on the other hand, is a cancer growth blocker known as a tyrosine kinase inhibitor (TKI), which is used to treat a wide range of leukaemias, myelodysplastic/myeloproliferative disorders, systemic mastocytosis, eosinophilia syndromes, raised dermal fibrosarcoma and gastrointestinal mesenchymal tumours. | [Chemical Properties]
Off-White Solid | [Uses]
3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one is used ads pharmaceutical intermediate, an imatinib intermediate. | [Uses]
Imatinib intermediate | [Uses]
Rasagiline intermediate | [Solubility in organics]
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one is soluble in Chloroform and Dichloromethane. |
|
|