| Identification | Back Directory | [Name]
4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime | [CAS]
55224-94-7 | [Synonyms]
AP-18
4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
4-(4-Chlorophenyl)-3-methyl-3-buten-2-oneoxime
4-(4-Chlorophenyl)-3-methylbut-3-en-2-one oxime
3-Buten-2-one, 4-(4-chlorophenyl)-3-methyl-, oxime | [Molecular Formula]
C11H12ClNO | [MDL Number]
MFCD00102250 | [MOL File]
55224-94-7.mol | [Molecular Weight]
209.67 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: >10mg/mL | [form ]
solid | [color ]
white to off-white | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| Hazard Information | Back Directory | [Description]
AP-18 is a channel blocker which reversibly inhibits TRPA1 (IC50s = 3.1 and 4.5 μM, human and mouse, respectively). It has minimal effect on TRPV1-4 or TRPM8. AP-18 has been used to study TRPA1 signaling in mice and rats as well as in vitro. | [Uses]
AP-18 is a channel blocker that inhibits TRPA1. | [Biological Activity]
Reversible TRPA1 channel blocker (IC 50 values are 3.1 and 4.5 μ M at human and mouse TRPA1 respectively). Blocks cinnameldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo . Also blocks TRPA1 pore dilation (IC 50 = 10.3 μM for the inhibition of Yo-Pro uptake). | [Biochem/physiol Actions]
AP-18 is a selective TRPA1 channel blocker. Transient receptor potential A1 (TRPA1) plays a central role for chemical sensing in the pain pathway. AP-18 is a novel TRPA1 channel blocker. It reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation demonstrating selectivity vs. TRPV11. AP-18 reverses CFA-induced mechanical hyperalgesia in mice. | [in vivo]
ap-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. this product is also capable to induce cinnamaldehyde-induced nociception and to block cold- and mustard oil-induced activation of mouse trpa1 but not capsaicin-induced activation 2. in addition, ap18 treatment reversed cfa-induced mechanical hyperalgesia in mice 2. thus, trpa1 is essential for sensitization of nociception. | [storage]
+4°C | [References]
References”Citations: |
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Sigma-Aldrich
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Energy Chemical
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