| Identification | Back Directory | [Name]
POLYGODIAL | [CAS]
6754-20-7 | [Synonyms]
Poligodial
POLYGODIAL
(-)-Tadeonal
Drim-7-ene-11,12-dial
Polygodial (Tadeonal)
1,4,4A,5,6,7,8,8A-Octahydro-5,5,8A-trimethyl-1,2-naphthalenedicarboxaldehyde
(1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde
1,2-Naphthalenedicarboxaldehyde, 1alpha,4,4aalpha,5,6,7,8,8A-octahydro-5,5,8abata-trimethyl-
1,2-Naphthalenedicarboxaldehyde, 1,4,4A,5,6,7,8,8A-octahydro-5,5,8A-trimethyl-, (2R,4as,8as)-
1,2-Naphthalenedicarboxaldehyde, 1,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-, (1R,4aS,8aS)-
1,2-Naphthalenedicarboxaldehyde, 1,4,4A,5,6,7,8,8A-octahydro-5,5,8A-trimethyl-, (1R-(1alpha,4abeta,8aalpha))- | [Molecular Formula]
C15H22O2 | [MDL Number]
MFCD00238664 | [MOL File]
6754-20-7.mol | [Molecular Weight]
234.33 |
| Chemical Properties | Back Directory | [Melting point ]
57° (Barnes, Loder) | [alpha ]
D24 -131° (c = 0.96 in ethanol) | [Boiling point ]
330.7±35.0 °C(Predicted) | [density ]
1.084±0.06 g/cm3(Predicted) | [RTECS ]
QJ2850000 | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble20mg/mL, clear | [form ]
powder | [color ]
white to beige | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. | [LogP]
3.522 (est) |
| Hazard Information | Back Directory | [Description]
Polygodial (6754-20-7) is a TRPA1 activator (EC50=400 nM).1?A naturally occurring drimane sesquiterpene dialdehyde found in a variety of plant species including water pepper (Polygonum hydropiper). Polygodial has been used in folk medicine for a variety of indications. Displays analgesic activity via desensitization of sensory neurons.2 | [Uses]
Polygodial is a naturally occurring antifungal and antinociceptive. | [Definition]
ChEBI: Polygodial is an aldehyde. | [Biochem/physiol Actions]
Polygodial is a selective activator of Transient Receptor Potential Anykrin 1 (TRPA1) channels. Initially painful, polygodial acts as an analgesic by desensitizing sensory neuron. Polygodial also has broad antifungal properties, and is cytotoxic against bacteria and algae. | [storage]
Store at -20°C | [References]
1) Escalera et al. (2008), TRPA1 mediates the noxious effects of natural sesquiterpene deterrents; J. Biol. Chem., 283 24136
2) Andre et al. (2004), Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdehydes unsaturated sesquiterpenes polygodial and drimanial in rats; Neuropharmacology, 46 590 |
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