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ChemicalBook--->CAS DataBase List--->521-12-0

521-12-0

521-12-0 Structure

521-12-0 Structure
IdentificationMore
[Name]

17b-Hydroxy-2a-methyl-5a-androstan-3-one propionate
[CAS]

521-12-0
[Synonyms]

17b-hydroxy-2a-methyl-5a-androstan-3-one propionate
DROMOSTANOLONE 17-PROPIONATE
DROMOSTANOLONE PROPIONATE
DROSTANOLONE PROPIONATE
17beta-Hydroxy-2alpha-methyl-5alpha-androstan-3-one propionate
17beta-Hydroxy-2alpha-methyl-5alpha-androstan-3-onepropionate
17-beta-hydroxy-2-alpha-methyl-5-alpha-androstan-3-onpropionate
2alpha-Methyl-4,5-dihydrotestosterone propionate
2alpha-Methyldihydrotestosterone propionate
2a-methyl-5a-androstane-17b-ol-3-onepropionate
2a-methyl-dihydro-testosteronepropionate
2M-DHTP
2MDTP
2-methyl-17-(1-oxopropoxy)-androstan-3-on
2-Methyl-3-oxoandrostan-17-yl propionate
2α-methyl-17β-(1-oxopropoxy)-5α-androstan-3-one
32379
357429
5alpha-Androstan-3-one, 17beta-hydroxy-2alpha-methyl-, propionate
Androstan-3-one, 2-methyl-17-(1-oxopropoxy)-, (2alpha,5alpha,17beta)-
[EINECS(EC#)]

208-303-1
[Molecular Formula]

C23H36O3
[MDL Number]

MFCD01669961
[Molecular Weight]

360.53
[MOL File]

521-12-0.mol
Chemical PropertiesBack Directory
[Melting point ]

114-120°C
[alpha ]

D +24°
[Boiling point ]

432.53°C (rough estimate)
[density ]

1.0669 (rough estimate)
[refractive index ]

1.4700 (estimate)
[storage temp. ]

Controlled Substance, -20°C Freezer
[solubility ]

DMF:30.0(Max Conc. mg/mL);83.21(Max Conc. mM)
DMSO:24.0(Max Conc. mg/mL);66.57(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);5.55(Max Conc. mM)
[form ]

A crystalline solid
[InChI]

InChI=1/C23H36O3/c1-5-21(25)26-20-9-8-17-16-7-6-15-12-19(24)14(2)13-23(15,4)18(16)10-11-22(17,20)3/h14-18,20H,5-13H2,1-4H3/t14-,15+,16+,17+,18+,20+,22+,23+/s3
[InChIKey]

NOTIQUSPUUHHEH-DEMPVMEFNA-N
[SMILES]

C[C@]12C[C@@H](C)C(=O)C[C@]1([H])CC[C@@]1([H])[C@]3([H])CC[C@H](OC(=O)CC)[C@@]3(C)CC[C@]21[H] |&1:1,3,8,12,14,18,24,28,r|
[CAS DataBase Reference]

521-12-0(CAS DataBase Reference)
[NIST Chemistry Reference]

Dromostanolone propionate(521-12-0)
Questions And AnswerBack Directory
[Antiestrogenic effects]

Dromostanolone Propionate is the propionate salt form of dromostanolone, a synthetic anabolic steroid related to dihydrotestosterone that has antiestrogenic effects. Dromostanolone inhibits the growth of estrogen receptor-presenting breast cancers; its virilizing effects limit its clinical usefulness.
Drostanolone propionate is a modified form of drostanolone, where a carboxylic acid ester (propionic acid) has been attached to the 17-beta hydroxyl group.Drostanolone Propionate is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone.
[Physiological effect]

Like testosterone and other androgenic hormones, dromostanolone binds to the androgen receptor. This causes downstream genetic transcriptional changes. This ultimately causes retention of nitrogen, potassium, and phosphorus; increases protein anabolism; and decreases amino acid catabolism. The antitumour activity of dromostanolone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.
Specifically, Masteron is the DHT hormone that has been structurally altered by the addition of a methyl group at the carbon 2 position, This protects the hormone from the metabolic breakdown by the 3-hydroxysteroid dehydrogenase enzyme, which is found in the skeletal muscle.
Questions and Answers (Q&A)Back Directory
[Description]

17b-Hydroxy-2a-methyl-5a-androstan-3-one propionate, also known as drostanolone propionate, is a synthetic anabolic-androgenic steroid. It has similar properties to dihydrotestosterone. It had been used for the treatment of breast cancer in the past. However, it is now mainly used by athletes and bodybuilder as an anabolic steroid. It has two major effects including enhancing the physical/athletic performance (such as endurance and strength) and enhancing physical health (muscle buildup and fat loss). It should be administrated via intramuscular injection instead of oral taking.
[References]

https://en.wikipedia.org/wiki/Drostanolone_propionate
http://www.chemspider.com/Chemical-Structure.194604.html
http://steroid.es/drostanolone.html
Chowdhury, M. S., et al. "A comparison of drostanolone propionate (Masteril) and nandrolone decanoate (Deca-durabolin) in the treatment of breast carcinoma. " 2.3(1976):203-206.
Hazard InformationBack Directory
[Chemical Properties]

White Solid
[Originator]

Drolban,Lilly,US,1961
[Uses]

An anabolic steroid used as an antineoplastic.
[Definition]

ChEBI: Drostanolone propionate is a steroid ester and a 3-oxo-5alpha-steroid. It has a role as an antineoplastic agent. It is functionally related to a metholone.?
[Preparation]

Drostanolone propionate is prepared from 9,11-dehydro-17a-methyl-testosterone raw material, reacts with lithium chloride and N-chlorosuccinimide to generate 9a,11-dichloro-17a-methyl- 95 testosterone is further prepared by esterification with propionin.
[Manufacturing Process]

A suspension of 10 grams of dihydrotestosterone in 500 cc of anhydrous benzene free of thiophene was mixed with10 cc of ethyl formate and 3 grams of sodium hydride and the mixture was stirred for 5 hours under an atmosphere of nitrogen and at a temperature of approximately 25°C. The resulting suspension was filtered, the resulting mixture of the sodium salt of the hydroxymethylene compound and the excess of sodium hydride was washed with benzene and dried. This mixture was slowly added to a vigorously stirred solution of 20 cc of concentrated hydrochloric acid in 500 cc of water, and the stirring was continued for 30 minutes at the end of which the precipitate was collected and well washed with distilled water. After drying in vacuo, there was obtained 9.7 grams of 2-hydroxymethylenedihydrotestosterone.
A mixture of 1 gram of 2-hydroxymethylene-dihydrotestosterone, 10 cc of pyridine and 2 cc of propionic anhydride was allowed to react at room temperature for 16 hours and then poured into water. The resulting suspension was heated for 1 hour on the steam bath to hydrolyze the excess of propionic anhydride, cooled and extracted with methylene dichloride. The extract was consecutively washed with dilute hydrochloric acid, sodium bicarbonate solution and water, dried over anhydrous sodium sulfate and evaporated to dryness under vacuum. There was thus obtained the dipropionate of 2-hydroxymethylenedihydrotestosterone which was treated with hydrogen, in methanol solution.
When the uptake of hydrogen ceased, the catalyst was filtered and the solution was evaporated to dryness under vacuum. The residue was dissolved in a mixture of benzene-hexane, transferred to a chromatographic column with neutral alumina and the product was eluted with mixtures of benzenehexane, gradually increasing the proportion of benzene in the mixture. Crystallization of the eluates from acetone-hexane yielded the propionate of 2α-methyldihydrotestosterone.
[Brand name]

Drolban (Lilly).
[Therapeutic Function]

Cancer chemotherapy
[Side effects]

As to be expected with all steroids, it's essential that you're aware of all potential side effects of Drostanolone propionate, before you consider a cycle. Side effects of drostanolone propionate include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire. It has no risk of liver damage.
Safety DataBack Directory
[Toxicity]

LD50 subcutaneous in mouse: > 2gm/kg
Spectrum DetailBack Directory
[Spectrum Detail]

Drostanolone propionate(521-12-0)MS
Drostanolone propionate(521-12-0)IR1
Drostanolone propionate(521-12-0)IR2
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