| Identification | Back Directory | [Name]
2,3-DIMETHYL-6-NITRO-2H-INDAZOLE | [CAS]
444731-73-1 | [Synonyms]
Pazopanib Impurity 19
3-Methly-6-nitroindazole
2,3-dimethyl-6-nitrobazole
2,3-Dimethyl-6-nitro-1H-i...
2,3-dimethyl-6-nitro-indazole
3-diMethyl-6-nitro-2H-indazole
2,3-DIMETHYL-6-NITRO-2H-INDAZOLE
2,3-dimethyl-6-nitro-1H-indazole
2H-Indazole, 2,3-diMethyl-6-nitro-
2,3-DIMETHYL-6-NITRO-2H-INDAZOLE ISO 9001：2015 REACH | [EINECS(EC#)]
610-189-7 | [Molecular Formula]
C9H9N3O2 | [MDL Number]
MFCD10703326 | [MOL File]
444731-73-1.mol | [Molecular Weight]
191.19 |
| Chemical Properties | Back Directory | [Melting point ]
183-186°C | [Boiling point ]
377.0±22.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
-0.55±0.30(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Uses]
2,3-Dimethyl-6-nitro-2H-indazole is an impurity in the synthesis of Pazopanib (P210925) hydrochloride, an oral angiogenesis inhibitor targeting VEGFR and PDGFR. | [structure and hydrogen bonding]
In the mol-ecule of 2,3-dimethyl-6-nitro-2H-indazole, C9H9N3O2, the indazole ring system is almost planar [maximum deviation = 0.019 (3) Å for the C atom bearing the nitro group]. In the crystal structure, inter-molecular C—H...O inter-actions link the mol-ecules into centrosymmetric dimers, forming R 2 2(18) ring motifs. Aromatic π–π contacts between indazole rings [centroid–centroid distances = 3.632 (1) and 3.705 (1)?] may further stabilize the structure[1].
| [References]
[1] Yan Chen, Ping Wei, Zheng Fang. “2,3-Dimethyl-6-nitro-2H-indazole.” Acta crystallographica. Section E, Structure reports online 65 Pt 8 (2009): o1775.
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