| Identification | More | [Name]
(R)-(-)-1,2-Propanediol | [CAS]
4254-14-2 | [Synonyms]
(2R)-PROPANE-1,2-DIOL
(R)-(-)-1,2-DIHYDROXYPROPANE
(R)-(-)-1,2-PROPANEDIOL
(R)-1,2-PROPANEDIOL
(R)-(-)-1,2-Propyleneglycol
(R)-(-)-PROPANEDIOL
(R)-(-)-PROPYLENE GLYCEROL
(R)-(-)-PROPYLENE GLYCOL
(R)-propane-1,2-diol
(R)-1,2-propandiol
(R-(--1,2-Propanediol))-IntermediateForTenofovir
Intermediate For Tenofovir
(R)-(-)-1,2-Propanediol,98%
(R)-(-)-1,2-Propanediol 4254-14-2
R-(-)-1,2-PROPANEDIOL/R-(-)-PROPYLENEGLYCEROL
(R)-(-)-Propylene glycerol, (R)-(-)-Propylene glycol
(2R)-1,2-Propanediol
R-1,2-PD | [Molecular Formula]
C3H8O2 | [MDL Number]
MFCD00066248 | [Molecular Weight]
76.09 | [MOL File]
4254-14-2.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless to light yellow liqui | [Melting point ]
-57C | [alpha ]
-17 º (c=neat) | [Boiling point ]
186-188 °C765 mm Hg(lit.) | [density ]
1.04 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.434(lit.)
| [Fp ]
225 °F
| [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Miscible with acetone, chloroform, ethanol (95%),
glycerin, and water; soluble at 1 in 6 parts of ether; not miscible
with light mineral oil or fixed oils, but will dissolve some
essential oils. | [form ]
clear liquid | [pka]
14.49±0.20(Predicted) | [color ]
Colorless to Light orange to Yellow | [Specific Gravity]
1.036 | [optical activity]
[α]20/D 16.5°, neat | [Sensitive ]
Hygroscopic | [Merck ]
14,7855 | [BRN ]
1718872 | [CAS DataBase Reference]
4254-14-2(CAS DataBase Reference) | [NIST Chemistry Reference]
R-(-)-1,2-propanediol(4254-14-2) |
| Safety Data | Back Directory | [Hazard Codes ]
F,Xn | [Risk Statements ]
R20:Harmful by inhalation.
R65:Harmful: May cause lung damage if swallowed.
R15:Contact with water liberates extremely flammable gases.
R10:Flammable. | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S43:In case of fire, use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add-Never use water) .
S7/8:Keep container tightly closed and dry . | [WGK Germany ]
1
| [F ]
3 | [HS Code ]
29053200 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to light yellow liqui | [Chemical Properties]
Propylene glycol is a clear, colorless, viscous, practically odorless
liquid, with a sweet, slightly acrid taste resembling that of glycerin. | [Uses]
R-(-)-1,2-Propanediol, is a chiral building blocks that can be used for variety of chemical synthesis. | [Definition]
ChEBI: (R)-propane-1,2-diol is a propane-1,2-diol. It has a role as a human metabolite and an Escherichia coli metabolite. It is an enantiomer of a (S)-propane-1,2-diol. | [Production Methods]
Propylene is converted to chlorohydrin by chlorine water and
hydrolyzed to 1,2-propylene oxide. With further hydrolysis, 1,2-
propylene oxide is converted to propylene glycol. | [Pharmaceutical Applications]
Propylene glycol has become widely used as a solvent, extractant,
and preservative in a variety of parenteral and nonparenteral
pharmaceutical formulations. It is a better general solvent than
glycerin and dissolves a wide variety of materials, such as
corticosteroids, phenols, sulfa drugs, barbiturates, vitamins (A
and D), most alkaloids, and many local anesthetics.
As an antiseptic it is similar to ethanol, and against molds it is
similar to glycerin and only slightly less effective than ethanol.
Propylene glycol is commonly used as a plasticizer in aqueous
film-coating formulations.
Propylene glycol is also used in cosmetics and in the food
industry as a carrier for emulsifiers and as a vehicle for flavors in
preference to ethanol, since its lack of volatility provides a more
uniform flavor. | [Safety]
Propylene glycol is used in a wide variety of pharmaceutical
formulations and is generally regarded as a relatively nontoxic
material. It is also used extensively in foods and cosmetics. Probably
as a consequence of its metabolism and excretion, propylene glycol
is less toxic than other glycols. Propylene glycol is rapidly absorbed
from the gastrointestinal tract; there is also evidence that it is
absorbed topically when applied to damaged skin. It is extensively
metabolized in the liver, mainly to lactic and pyruvic acids, and is
also excreted unchanged in the urine.
In topical preparations, propylene glycol is regarded as
minimally irritant,although it is more irritant than glycerin.
There have been some reports of contact dermatitis associated with
propylene glycol.Some local irritation is produced upon
application to mucous membranes or when it is used under
occlusive conditions.Parenteral administration may cause pain
or irritation when propylene glycol is used in high concentration.
Propylene glycol is estimated to be one-third as intoxicating as
ethanol, with administration of large volumes being associated with
adverse effects most commonly on the central nervous system,
especially in neonates and children.Other adverse reactions
reported, though generally isolated, include: ototoxicity;cardiovascular
effects; seizures; and hyperosmolarity and lactic
acidosis, both of which occur most frequently in patients with
renal impairment. Adverse effects are more likely to occur following
consumption of large quantities of propylene glycol or on
adminstration to neonates, children under 4 years of age, pregnant
women, and patients with hepatic or renal failure. Adverse events
may also occur in patients treated with disulfiram or metronidazole.
On the basis of metabolic and toxicological data, the WHO has
set an acceptable daily intake of propylene glycol at up to 25 mg/kg
body-weight.Formulations containing 35% propylene glycol
can cause hemolysis in humans.
In animal studies, there has been no evidence that propylene
glycol is teratogenic or mutagenic. Rats can tolerate a repeated oral
daily dose of up to 30 mL/kg body-weight in the diet over 6 months,
while the dog is unaffected by a repeated oral daily dose of 2 g/kg in
the diet for 2 years.
(mouse, IP): 9.72 g/kg
(mouse, IV): 6.63 g/kg
(mouse, oral): 22.0 g/kg
(mouse, SC): 17.34 g/kg
(rat, IM): 0.01 g/kg
(rat, IP): 6.66 g/kg
(rat, IV): 6.42 g/kg
(rat, oral): 0.02 g/kg
(rat, SC): 22.5 g/kg | [storage]
At cool temperatures, propylene glycol is stable in a well-closed
container, but at high temperatures, in the open, it tends to oxidize,
giving rise to products such as propionaldehyde, lactic acid, pyruvic
acid, and acetic acid. Propylene glycol is chemically stable when
mixed with ethanol (95%), glycerin, or water; aqueous solutions
may be sterilized by autoclaving.
Propylene glycol is hygroscopic and should be stored in a wellclosed
container, protected from light, in a cool, dry place. | [Incompatibilities]
Propylene glycol is incompatible with oxidizing reagents such as
potassium permanganate. | [Regulatory Status]
GRAS listed. Accepted for use as a food additive in Europe.
Included in the FDA Inactive Ingredients Database (dental
preparations; IM and IV injections; inhalations; ophthalmic, oral,
otic, percutaneous, rectal, topical, and vaginal preparations).
Included in nonparenteral and parenteral medicines licensed in the
UK. Included in the Canadian List of Acceptable Non-medicinal
Ingredients. |
|
|