| Identification | More | [Name]
1-Methoxy-2-propanol | [CAS]
107-98-2 | [Synonyms]
1,2-PROPYLENEGLYCOL-1-METHYL ETHER
1,2-PROPYLENE GLYCOL 1-MONOMETHYL ETHER
1-Methoxy-2-hydroxypropane
1-METHOXY-2-PROPANOL
1-METHOXYPROPAN-2-OL
A-PROPYLENE GLYCOL MONOMETHYL ETHER
ARCOSOLV(R) PM
'DOWANOL(R) PM'
DOWANOL(TM) PM
GLYCOL ETHER PM
METHYL PROPASOL
METHYL PROXITOL
PM
PM-EL
PROPYLENE GLYCOL 1-MONOMETHYL ETHER
PROPYLENE GLYCOL METHYL ETHER
PROPYLENEGLYCOL MONOMETHYL ETHER
RHOROPYLENE GLYCOL ALPHA-MONOMETHYL ETHER
1-methoxy-2-propano
1-methoxypropan-2-olr | [EINECS(EC#)]
203-539-1 | [Molecular Formula]
C4H10O2 | [MDL Number]
MFCD00004537 | [Molecular Weight]
90.12 | [MOL File]
107-98-2.mol |
| Chemical Properties | Back Directory | [Appearance]
Propylene glycol monomethyl ether is a color-
less liquid. Ethereal odor. The Odor Threshold is 10 ppm. | [Melting point ]
-97 °C
| [Boiling point ]
118-119 °C(lit.)
| [density ]
0.922 g/mL at 25 °C(lit.)
| [vapor density ]
3.12 (vs air)
| [vapor pressure ]
10.9 mm Hg ( 25 °C)
| [refractive index ]
n20/D 1.403(lit.)
| [Fp ]
93 °F
| [storage temp. ]
Store at +2°C to +25°C. | [solubility ]
water: miscible | [form ]
Liquid | [pka]
14.49±0.20(Predicted) | [color ]
Colorless | [Odor]
sweet ether-like odor | [PH]
4-7 (200g/l, H2O, 20℃) | [Stability:]
Stable. Highly flammable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, water. Moisture-sensitive. | [explosive limit]
1.7-11.5%(V) | [Water Solubility ]
soluble | [Sensitive ]
Hygroscopic | [BRN ]
1731270 | [Exposure limits]
TLV-TWA 100 ppm (370 mg/m3) (ACGIH); STEL 150 ppm (555 mg/m3) (ACGIH). | [InChIKey]
ARXJGSRGQADJSQ-UHFFFAOYSA-N | [LogP]
0.37 at 20℃ | [CAS DataBase Reference]
107-98-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Propan-2-ol, 1-methoxy-(107-98-2) | [EPA Substance Registry System]
107-98-2(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R10:Flammable. | [Safety Statements ]
S24:Avoid contact with skin .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S24/25:Avoid contact with skin and eyes . | [OEB]
A | [OEL]
TWA: 100 ppm (360 mg/m3), STEL: 150 ppm (540 mg/m3) | [RIDADR ]
UN 3092 3/PG 3
| [WGK Germany ]
1
| [RTECS ]
UB7700000
| [Autoignition Temperature]
532 °F | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29094919 | [Safety Profile]
Moderately toxic by
intravenous route. Mildly toxic by ingestion,
inhalation, and skin contact. Human
systemic effects by inhalation: general
anesthesia, nausea. A skin and eye irritant.
An experimental teratogen. Many glycol
ethers have dangerous human reproductive
effects. Very dangerous fire hazard when
exposed to heat or flame; can react with
oxidizing materials. To fight fire, use foam,
CO2, dry chemical. When heated to
decomposition it emits acrid smoke and
irritating fumes. Used as a solvent and in
solvent-sealing of cellophane. See also
GLYCOL ETHERS and ETHYLENE
GLYCOL MONOMETHYL ETHER. | [Hazardous Substances Data]
107-98-2(Hazardous Substances Data) | [Toxicity]
dog,LD50,intravenous,2gm/kg (2000mg/kg),LUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: ATAXIABEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972. |
| Hazard Information | Back Directory | [General Description]
A colorless liquid. Flash point near 89°F. Less dense than water. Contact irritates skin, eyes and mucous membranes. Prolonged exposure to vapors may cause coughing, shortness of breath, dizziness and intoxication. Vapors heavier than air. Used as a solvent and as an antifreeze agent. | [Reactivity Profile]
1-METHOXY-2-PROPANOL(107-98-2) is a methoxy alcohol derivative. The ether being relatively unreactive. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides. | [Air & Water Reactions]
Highly flammable. Soluble in water. Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick 1979 p.151-154, 164]. | [Hazard]
Flammable, moderate fire risk. TLV: 100
ppm; STEL 150 ppm.
| [Health Hazard]
VAPOR: Irritating to eyes, nose, and throat. LIQUID: Irritating to skin and eyes. | [Potential Exposure]
Propylene glycol monomethyl ether is
used as a solvent for coatings; cellulose esters and acrylics;
acrylics dyes; inks, and stains. It may also be used as
a heat-transfer fluid. | [Fire Hazard]
FLAMMABLE. Flashback along vapor trail may occur. Vapor may explode if ignited in an enclosed area. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts
the skin, remove contaminated clothing and wash
immediately with soap and water. Seek medical attention
immediately. If this chemical has been inhaled, remove from
exposure, begin rescue breathing (using universal precau-
tions, including resuscitation mask) if breathing has stopped
and CPR if heart action has stopped. Transfer promptly to a
medical facility. When this chemical has been swallowed,
get medical attention. Give large quantities of water and
induce vomiting. Do not make an unconscious person vomit. | [Shipping]
UN3092 1-Methoxy-2-propanol, Hazard Class: 3;
Labels: 3-Flammable liquid. | [Incompatibilities]
Vapor may form explosive mixture
with air. Incompatible with oxidizers (chlorates, nitrates,
peroxides, permanganates, perchlorates, chlorine, bromine,
fluorine, etc.); contact may cause fires or explosions. Keep
away from alkaline materials, strong bases, strong acids,
oxoacids, epoxides, acid chlorides, acid anhydrides, isocya-
nates, aluminum, and copper. Hygroscopic (i.e., absorbs
moisture from the air). May slowly form reactive peroxides
during prolonged storage or on exposure to air and light. | [Chemical Properties]
colourless liquid | [Chemical Properties]
Propylene glycol monomethyl ether is a color-
less liquid. Ethereal odor. The Odor Threshold is 10 ppm. | [Chemical Properties]
Propylene glycol monomethyl ether is a colorless liquid with a sweet ether-like
odor and bitter taste. It is soluble in water, ether, acetone, and benzene. | [Waste Disposal]
Dissolve or mix the
material with a combustible solvent and burn in a chemical
incinerator equipped with an afterburner and scrubber.
All federal, state, and local environmental regulations must
be observed. | [Uses]
A glycol ether and a good biological indicator of exposure. | [Uses]
PGME is used as a solvent for cellulose, acrylics, dyes, inks, and cellophane. | [Uses]
Propylene glycol monomethyl ether is primarily used in the manufacture of
lacquers and paints, as an anti-freeze in industrial engines, a tailing agent for inks
used on very high-speed presses, a coupling agent for resins and dyes in waterbased
inks, and a solvent for celluloses, acrylics, dyes, inks, and stains. It is also
used in cleaning products such as glass and rug cleaners, carbon and grease
removers, and paint and varnish removers; and in pesticide formulations as a
solvent for applications to crops and animals. | [Flammability and Explosibility]
Flammable | [Synthesis]
1-Methoxy-2-propanol is used as a reagent in the synthesis of 2-amino-3-carboxy-4-phenylthiophenes, which acts as a protein kinase C inhibitors. It is also used as a reagent in the synthesis of metolachlor. | [Advantages]
1-Methoxy-2-propanol has been used as an antifreeze material, principally in ebullient cooling systems and in some heavy-duty diesel engines. Because an azeotrope is formed between 1-methoxy-2-propanol and water, freeze protection also is provided in the vapor phase in ebullient cooling applications. On the other hand, it is more volatile and is more readily expelled along with water vapor through the crankcase vent system. It also maintains lower metal temperatures than comparative glycolbased coolants. This was an advantage in rotary engines.
| [Toxicity evaluation]
Contact irritates skin, eyes and mucous membranes. Prolonged exposure to vapors may cause coughing, shortness of breath, dizziness and intoxication. Vapors heavier than air. Used as a solvent and as an antifreeze agent. The oral LD50 of rats was 6.6g/kg. The skin irritation is not obvious, but the toxic dose can be absorbed through the skin. The main manifestations of animal poisoning were inhibition and incomplete anesthesia. Half of the rats died when they were exposed to steam concentration of 40.18g/m3 for 5 ~ 6 hours. the impact of 1-methoxypropanol-2 (MEP) for the stimulation of an inflammatory response in human respiratory mucosa, we exposed 22 primary cell cultures of nasal respiratory epithelia of healthy individuals to MEP concentrations at the level of the German MAK-value (100ppm) and to the 10-fold concentration (1000ppm). |
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