| Identification | More | [Name]
2-Chloro-4-iodoaniline | [CAS]
42016-93-3 | [Synonyms]
2-CHLORO-4-IODOANILINE
2-Chloro-4-iodoaniline,98%
2-Chloro-4-iodo-phenylamine | [EINECS(EC#)]
628-520-9 | [Molecular Formula]
C6H5ClIN | [MDL Number]
MFCD00025298 | [Molecular Weight]
253.47 | [MOL File]
42016-93-3.mol |
| Chemical Properties | Back Directory | [Appearance]
grey to light orange crystalline powder | [Melting point ]
70-73 °C (lit.) | [Boiling point ]
281.7±25.0 °C(Predicted) | [density ]
1.9011 (estimate) | [storage temp. ]
Refrigerated. | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
powder to crystal | [pka]
1.86±0.10(Predicted) | [color ]
Light yellow to Brown to Dark green | [Sensitive ]
Light Sensitive | [BRN ]
2081106 | [CAS DataBase Reference]
42016-93-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T,N,Xi,Xn | [Risk Statements ]
R25:Toxic if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29214200 |
| Hazard Information | Back Directory | [Chemical Properties]
grey to light orange crystalline powder | [Uses]
2-Chloro-4-iodoaniline is a chemical compound that has been synthesized
for use as a reagent. It has been used to produce the drug cobimetinib,
which is used in the treatment of cancer. 2-Chloro-4-iodoaniline can be
prepared by reaction of magnesium with 2-chloroacetaldehyde and nitric
acid. This reagent is also useful for preparing Grignard reagents.
2-Chloro-4-iodoaniline can be used to deaminate ketones, nitrates, and
chlorides in high yield.
2,4,6-trichlorophenylalanine is an organic compound that contains all
three functional groups: a chloride group, a ketone group, and an amino
group. The chlorinated carbon atom of the chloride group makes it a good
nucleophile and electrophile. |
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