| Identification | More | [Name]
Sodium omadine | [CAS]
3811-73-2 | [Synonyms]
1-HYDROXY-2(1H)-PYRIDINETHIONE SODIUM SALT
1-HYDROXY-2-PYRIDINETHIONE SODIUM SALT
1-HYDROXYPYRIDINE-2-THIONE SODIUM SALT
2,2-MERCAPTOPYRIDINE-N-OXIDE, SODIUM SALT
2-MERCAPTOPYRIDINE-1-OXIDE SODIUM SALT
2-MERCAPTOPYRIDINE-N-OXIDE
2-MERCAPTOPYRIDINE N-OXIDE SODIUM SALT
2-PYRIDINETHIOL-1-OXIDE SODIUM SALT
MERCAPTOPYRIDINE N-OXIDE SODIUM SALT
N-Hydroxy-2-pyridinethione sodium salt
N-HYDROXYPYRIDINETHIONE SODIUM SALT
PYRITHIONE SODIUM
PYRITHIONE SODIUM SALT
SODIUM-2-PYRIDINETHIOL-1-OXIDE
SODIUM OMADINE
SODIUM PYRIDINE-2-THIOLATE 1-OXIDE HYDRATE
SODIUM PYRITHIONE
(1-hydroxy-2-pyridinethione),sodiumsalt,tech.
(2-pyridylthio)-sodiun-oxide
2-pyridinethiol,n-oxide,sodiumsalt | [EINECS(EC#)]
223-296-5 | [Molecular Formula]
C5H4NNaOS | [MDL Number]
MFCD01941547 | [Molecular Weight]
149.15 | [MOL File]
3811-73-2.mol |
| Chemical Properties | Back Directory | [Definition]
Apparently exists in equilibrium with the -SH form. Forms chelates with iron, manganese, zinc, etc. | [Appearance]
Clear solution | [Melting point ]
-25 °C | [Boiling point ]
109 °C | [density ]
1.22 | [vapor pressure ]
0-0Pa at 25℃ | [refractive index ]
1.4825 | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
H2O: 0.1 M at 20 °C, clear, faintly yellow
| [form ]
Solution | [color ]
very deep brown
| [Water Solubility ]
54.7 g/100 mL | [Sensitive ]
Hygroscopic | [λmax]
334nm(H2O)(lit.) | [Detection Methods]
T,NMR | [Merck ]
14,7994 | [BRN ]
4026050 | [InChIKey]
WNGMMIYXPIAYOB-UHFFFAOYSA-M | [LogP]
-2.38 at 20℃ and pH7 | [Surface tension]
65.013-72.6mN/m at 1-1.02g/L and 20-20.1℃ | [Uses]
sodium pyrithione is a preservative that is not commonly used because of some level of toxicity. It is prohibited in Canada, and it is on the eu Annex II list of substances that must not form part of a cosmetic product composition. | [CAS DataBase Reference]
3811-73-2(CAS DataBase Reference) | [EPA Substance Registry System]
3811-73-2(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R36/38:Irritating to eyes and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S24/25:Avoid contact with skin and eyes .
S37/39:Wear suitable gloves and eye/face protection . | [RIDADR ]
UN 3334 | [WGK Germany ]
3
| [RTECS ]
UT9000000
| [F ]
3-13 | [TSCA ]
Yes | [HS Code ]
29333990 | [Safety Profile]
Poison by
intraperitoneal and intravenous routes.
Moderately toxic by ingestion, subcutaneous
and parenteral routes. Used in preservation
of cosmetics. When heated to
decomposition it emits very toxic fumes of
Na2O, NOx, and SOx. See also
MERCAPTANS. |
| Hazard Information | Back Directory | [Description]
Sodium pyrithione is mainly used for anti-mildew and antibacterial products in the fields of daily chemicals (shampoo and hair care products), architectural coatings, adhesives, sealants, pesticides, textiles, leather products, metal working fluids, etc. It can also be formulated for disinfection agents, detergents and medical broad-spectrum antifungal dermatological products. At the same time, it is also an effective fungicide and an excellent common disinfectant for fruit trees, peanuts, wheat, vegetables and other crops. Its derivative product, zinc pyrithione, is also a commonly used fungicide for daily chemicals.
 | [Chemical Properties]
Clear solution | [Application]
2-Mercaptopyridine N-oxide sodium salt is one of the active components in paint, sealants, shampoo, adhesive and aerosol due to its anti-microbial activity. In biochemistry studies, it is utilized to transport zinc into cells. Further, it is used to form bidentate oxothiolane chelates with transition metals. It acts as a stabilizer and viscosity building provider in weak basic or neutral medium. | [Brand name]
Sodium Omadine (Olin). | [General Description]
2-Mercaptopyridine N-oxide acts as labelling agent during indium-111 labelling of human platelets. It acts as bioactive ligand and forms palladium and platinum complexes, which were tested as potential antitrypanosomal agents. | [Biochem/physiol Actions]
2-Mercaptopyridine N-oxide is a zinc ionophore that transports zinc into cells. | [Purification Methods]
When recrystallised from water, it assayed as 98.7% based on AgNO3 titration [Krivis et al. Anal Chem 35 966 1963; see also Krivis et al. Anal Chem 48 1001 1976, and Barton & Crich J Chem Soc, Perkin Trans 1 1603, 1613 1986]. [Beilstein 21/7 V 151.] | [Mode of action]
Pyrithione Sodium is the sodium salt form of pyrithione, a fungistatic and antimicrobial derivative of aspergillic acid. Although the exact mechanism of action remains to be fully elucidated, pyrithione sodium appears to interfere with membrane transport ultimately leading to a loss of metabolic control. |
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