| Identification | More | [Name]
4-Chloro-3-fluoroaniline | [CAS]
367-22-6 | [Synonyms]
3-FLUORO-4-CHLOROANILINE
4-CHLORO-3-FLUOROANILINE
4-CHLORO-3-FLUORO-PHENYLAMINE
BUTTPARK 44\01-97
4-Chloro-3-fluoroanline
4-Chloro-3-fluoroaniline 98%
4-Chloro-3-fluoroaniline98% | [EINECS(EC#)]
206-683-3 | [Molecular Formula]
C6H5ClFN | [MDL Number]
MFCD01090987 | [Molecular Weight]
145.56 | [MOL File]
367-22-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
61 | [Boiling point ]
226°C(lit.) | [density ]
1.349±0.06 g/cm3(Predicted) | [Fp ]
60 - 62°C | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
2.94±0.10(Predicted) | [color ]
White to Gray to Red | [BRN ]
2716278 | [CAS DataBase Reference]
367-22-6(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Uses]
4-Chloro-3-fluoroaniline is used in the synthesis of Methyl 5-Chloro-4-fluoro-1H-indole-2-carboxylate; a key intermediate towards phosphoindole inhibitors of HIV non-nucleoside reverse transcriptase. 4-Chloro-3-fluoroaniline is also used in the synthesis of 3-Deschloro-4-desfluoro-4-chloro-3-fluoro Gefitinib (D289540) which is an impurity of the tyrosine kinase inhibitor Gefitinib. |
| Safety Data | Back Directory | [Hazard Codes ]
T,Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
UN2811 | [WGK Germany ]
3 | [Hazard Note ]
Toxic | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29214200 |
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