| Identification | More | [Name]
Tilorone dihydrochloride | [CAS]
27591-69-1 | [Synonyms]
2,7-BIS[2-(DIETHYLAMINO)ETHOXY]-9-FLUORENONE DIHYDROCHLORIDE
TILORONE DIHYDROCHLORIDE
TILORONE HYDROCHLORIDE
2,7-bis(2-(diethylamino)ethoxy)-9h-fluoren-9-ondihydrochloride
2,7-bis(2-(diethylamino)ethoxy)-fluoren-9-ondihydrochloride
2,7-bis(2-(diethylamino)ethoxy)-fluoren-9-onedihydrochloride
bis-deae-fluorenonehydrochloride
nsc-143969
TILORONE 2HCL | [Molecular Formula]
C25H36Cl2N2O3 | [MDL Number]
MFCD00134071 | [Molecular Weight]
483.47 | [MOL File]
27591-69-1.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
R40:Limited evidence of a carcinogenic effect. | [Safety Statements ]
S7:Keep container tightly closed .
S22:Do not breathe dust .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [RTECS ]
LL9000000
| [HS Code ]
2922.39.4500 | [Toxicity]
LD50 in mice, rats (single dose): 959, 852 mg/kg orally; 145, 244 mg/kg i.p. (Krueger, Mayer) |
| Hazard Information | Back Directory | [Description]
Tilorone is an orally active, antiviral compound that induces interferon production and is reported to have antitumor, anti-inflammatory, and neuroprotective actions.1,2,3 With chronic administration, tilorone induces lysosomal glycosaminoglycan storage, rendering glycosaminoglycans resistant to enzymatic degradation.4 | [Chemical Properties]
Orange-yellow crystalline powder | [Uses]
antiviral | [Definition]
ChEBI: Tilorone dihydrochloride is the dihydrochloride salt of tilorone. It is used as an antiviral drug to treat influenza, herpes infection, viral hepatitis, acute respiratory viral infections and SARS. It has a role as an anti-inflammatory agent, an antineoplastic agent, an interferon inducer, a nicotinic acetylcholine receptor agonist and an antiviral drug. It contains a tilorone(2+). | [Brand name]
Tilorone is INN. | [General Description]
Effect of tilorone dihydrochloride on the changes of transmembrane potential of mitochondrial membranes of the isolated rat hepatocytes has been investigated. Tilorone dihydrochloride is an orally active, interferon-inducing antiviral agent. |
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