| Identification | More | [Name]
Trimethoprim lactate salt | [CAS]
23256-42-0 | [Synonyms]
2,4-DIAMINO-5-(3,4,5-TRIMETHOXYBENZYL)PYRIMIDINE LACTATE
2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine lactate salt
TRIMETHOPRIM LACTATE
TRIMETHOPRIM LACTATE SALT
TRIMETHOPRIM LACTIC ACID
lactic acid, compound with 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine (1:1) | [EINECS(EC#)]
245-533-1 | [Molecular Formula]
C17H24N4O6 | [MDL Number]
MFCD00171722 | [Molecular Weight]
380.4 | [MOL File]
23256-42-0.mol |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R43:May cause sensitization by skin contact.
R61:May cause harm to the unborn child. | [Safety Statements ]
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S53:Avoid exposure-obtain special instruction before use . | [RIDADR ]
UN 2811 | [WGK Germany ]
3
| [HazardClass ]
6.1(b) | [PackingGroup ]
III |
| Hazard Information | Back Directory | [Chemical Properties]
Crystalline | [Uses]
Trimethoprim lactate salt is an antibacterial agent. | [Biological Activity]
The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to prokaryote-specific dihydrofolate reductase (DHFR) and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis. |
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