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ChemicalBook--->CAS DataBase List--->2244520-98-5

2244520-98-5

2244520-98-5 Structure

2244520-98-5 Structure
IdentificationBack Directory
[Name]

Homo-PROTAC cereblon degrader 1
[CAS]

2244520-98-5
[Synonyms]

Homo-PROTAC cereblon degrader 1
[Molecular Formula]

C32H32N6O10
[MDL Number]

MFCD31813818
[MOL File]

2244520-98-5.mol
[Molecular Weight]

660.64
Chemical PropertiesBack Directory
[Boiling point ]

978.5±65.0 °C(Predicted)
[density ]

1.527±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 200 mg/mL (302.74 mM)
[form ]

Solid
[pka]

10.44±0.40(Predicted)
[color ]

Light yellow to yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Description]

Homo-PROTAC Cereblon Degrader 1 is a highly potent and efficient Cereblon (CRBN) degrader with minimal effects on IKZF1 and IKZF3.
[Uses]

Homo-PROTAC cereblon degrader 1 (compound 15a) is a highly potent and efficient Cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3[1].
[IC 50]

Cereblon
[References]

[1] Steinebach C, et al. Homo-PROTACs for the Chemical Knockdown of Cereblon. ACS Chem Biol. 2018 Sep 21;13(9):2771-2782. DOI:10.1021/acschembio.8b00693
Spectrum DetailBack Directory
[Spectrum Detail]

Homo-PROTAC cereblon degrader 1(2244520-98-5)1HNMR
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