| Identification | Back Directory | [Name]
Acid-PEG4-mono-methyl ester | [CAS]
2028284-75-3 | [Synonyms]
COOH-PEG4-COOMe
CAS_2028284-75-3
acid-PEG3-methyl ester
Acid-PEG4-mono-methyl ester
MeOOCCH2CH2O-PEG3-CH2CH2COOH
3-Oxo-2,6,9,12,15-pentaoxaoctadecan-18-oic acid
4,7,10,13-Tetraoxahexadecanedioic acid, 1-methyl ester | [Molecular Formula]
C13H24O8 | [MDL Number]
MFCD29041550 | [MOL File]
2028284-75-3.mol | [Molecular Weight]
308.325 |
| Chemical Properties | Back Directory | [Boiling point ]
433.8±40.0 °C(Predicted) | [density ]
1.156±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [pka]
4.28±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
Acid-PEG4-mono-methyl ester is a PEG linker with a carboxylic acid and methyl ester group. Methyl ester can be hydrolyzed under strong basic condition. The carboxylic acid can react with primary amines in the presence of EDC and HATU to form stable amide bonds. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. | [Uses]
Acid-PEG4-mono-methyl ester is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] Kanazaki K, et al. Feasibility of poly(ethylene glycol) derivatives as diagnostic drug carriers for tumor imaging. J Control Release. 2016 Mar 28;226:115-23. DOI:10.1016/j.jconrel.2016.02.017 |
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