| Identification | Back Directory | [Name]
S-acetyl-PEG3-acid | [CAS]
1421933-33-6 | [Synonyms]
CAS_1421933-33-6
S-acetyl-PEG3-acid
S-acetyl-PEG3-COOH
S-Acetyl-PEG3-C2-acid
Acid-PEG3-S-methyl ethanethioate
14-Oxo-4,7,10-trioxa-13-thiapentadecanoic acid
4,7,10-Trioxa-13-thiapentadecanoic acid, 14-oxo- | [Molecular Formula]
C11H20O6S | [MDL Number]
MFCD22574765 | [MOL File]
1421933-33-6.mol | [Molecular Weight]
280.34 |
| Chemical Properties | Back Directory | [Boiling point ]
421.4±40.0 °C(Predicted) | [density ]
1.193±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [pka]
4.28±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
S-acetyl-PEG3-acid is a PEG linker containing a sulfur acetyl group and a terminal carboxylic acid. The sulfur acetyl group can be deprotected to produce a thiol moiety. The terminal carboxylic acid can react with primary amines in the presence of EDC or HATU to produce amide bonds. The hydrophilic PEG linker increase the water solubility of the compound in aqueous media. | [Uses]
S-Acetyl-PEG3-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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