| Identification | Back Directory | [Name]
Conivaptan hydrochloride | [CAS]
168626-94-6 | [Synonyms]
Vaprisol
Conivaptan HCI
Conivaptan HCl
Unii-75L57R6X36
Conivaptan HCl (YM 087)
Conivaptan hydrochkoride
Conivaptan hydrochloride
Conivaptan hydrochloride, >=99%
Conivaptan hydrochloride [usan]
Conivaptan hydrochloride USP/EP/BP
N-[4-(2-Methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamid
N-[4-(2-Methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamide hydrochloride
N-[4-[(4,5-Dihydro-2-methylimidazo[4,5-d][benzazepin-6(1H)-yl)carbonyl]phenyl-[1,1'-biphenyl]-2-carboxamide hydrochloride
N-[4-[(4,5-Dihydro-2-MethyliMidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-[1,1'-Biphenyl]-2-carboxaMide Hydrochloride
N-(4-(2-methyl-3,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide hydrochloride
[1,1'-Biphenyl]-2-carboxamide,N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-,hydrochloride
N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-[1,1'-biphenyl]-2-carboxamide, hydrochloride (1:1)
(1,1'-Biphenyl)-2-carboxamide, N-(4-((4,5-dihydro-2-methylimidazo(4,5-D)(1)benzazepin-6(1H)-yl)carbonyl)phenyl)-, monohydrochloride
1,1'-Biphenyl]-2-carboxamide, N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-, hydrochloride (1:1)
Conivaptan HydrochlorideQ: What is
Conivaptan Hydrochloride Q: What is the CAS Number of
Conivaptan Hydrochloride Q: What is the storage condition of
Conivaptan Hydrochloride Q: What are the applications of
Conivaptan Hydrochloride | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C32H26N4O2.HCl | [MDL Number]
MFCD00945712 | [MOL File]
168626-94-6.mol | [Molecular Weight]
535.04 |
| Chemical Properties | Back Directory | [Melting point ]
>250° | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [InChIKey]
BTYHAFSDANBVMJ-UHFFFAOYSA-N | [SMILES]
C12=CC=CC=C1N(CCC1N=C(C)NC2=1)C(=O)C1=CC=C(NC(=O)C2C=CC=CC=2C2=CC=CC=C2)C=C1.Cl |
| Hazard Information | Back Directory | [Description]
Arginine vasopressin is intimately involved in volume homeostasis, and
elevated levels of arginine vasopressin are responsible for the pathogenesis and
progression of diseases with an imbalance of sodium and water, particularly
congestive heart failure. To restore homeostasis, antagonism of vasopressin
receptors is a practical solution. As such, conivaptan has been developed and
launched as a dual V1a and V2 vasopressin receptor antagonist. As a competitive,
reversible inhibitor of both subtypes, conivaptan can modulate systemic vascular
resistance through the V1a receptor (Ki ? 0.48 nM) distributed in vascular smooth
muscle cells, cardiomyocytes, hepatocytes, and platelets and blocks the renal V2
receptor (Ki ? 3.04 nM) resulting in enhanced diuresis, thereby increasing serum
sodium concentration and reducing total body volume. Currently, the drug is
approved for the management of refractory hyponatremia and potentially lifethreatening
sodium and water imbalance, but it has shown promise as a potential
treatment option for other diseases, such as congestive heart failure, syndrome of
antidiuretic hormone, diabetes insipidus, and liver cirrhosis. | [Chemical Properties]
White to Off-White Solid | [Originator]
Yamanouchi (Japan) | [Uses]
Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin receptor antagonist). | [Uses]
Used in treatment of congestive heart failure. | [Definition]
ChEBI: The hydrochloride salt of conivaptan. It is an antagonist for two of the three types of arginine vasopressin (AVP) receptors, V1a and V2, and is used for the treatment of hyponatraemia (low blood sodium levels) cau
ed by syndrome of inappropriate antidiuretic hormone (SIADH). | [Brand name]
Vaprisol (Astellas). | [storage]
Desiccate at RT |
|
|