| Identification | More | [Name]
4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT | [CAS]
15220-11-8 | [Synonyms]
4-MUS
4-MU-SULFATE K
Einecs 239-272-2
4-METHYLUMBELLIFERYL SULFATE POTASSIUM
POTASSIUM 4-METHYLUMBELLIFERONE SULFATE
Potassium 4-methylumbelliferyl sulfate
4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT
4-methylumberiferryl sulfate potassium salt
4-METHYLUMBELLIFERYL SULPHATE POTASSIUM SALT
4-METHYLUMBELLIFERONE SULFATE POTASSIUM SALT
potassiuM 4-Methyl-2-oxo-2H-chroMen-7-yl sulfate
7-HYDROXY-4-METHYLCOUMARIN SULFATE POTASSIUM SALT
potassium (4-methyl-2-oxo-2H-1-benzopyran-7-yl)sulphate
4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT CRYSTALLINE
4-methyl-7-(sulfooxy)-2h-1-benzopyran-2-onpotassiumsalt
4-Methyl-7-(potassiooxysulfonyloxy)-2H-1-benzopyran-2-one
4-METHYL-7-(SULFOOXY)-2H-1-BENZOPYRAN-2-ONE POTASSIUM SALT
2H-1-Benzopyran-2-one, 4-methyl-7-(sulfooxy)-, potassium salt
4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT FOR FLUORESCENCE 99+%
2H-1-Benzopyran-2-one, 4-methyl-7-(sulfooxy)-, potassium salt (1:1)
4-MU-sulfate K *1 g* [4-MethyluMbelliferyl sulfate, potassiuM salt]
Sulfuric acid potassium 4-methyl-2-oxo-2H-1-benzopyran-7-yl ester salt | [EINECS(EC#)]
239-272-2 | [Molecular Formula]
C10H7KO6S | [MDL Number]
MFCD00016970 | [Molecular Weight]
294.32 | [MOL File]
15220-11-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Crystalline Solid | [Melting point ]
287-290°C | [storage temp. ]
2-8°C
| [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Powder | [color ]
White to Pale Yellow | [Water Solubility ]
Soluble in water at 5mg/ml | [Usage]
Met-enkephalin analog found in opioid extracts of brain and adrenal chromaffin cells that is an artifact generated by trichloroacetic acid extraction. MUS is used as a fluorimetric substrate for arylsulphatase enzyme.
Subsitution of the hydroxyl g | [BRN ]
3803203 | [Stability:]
Stable in unbuffered solution for several months at -20° | [CAS DataBase Reference]
15220-11-8(CAS DataBase Reference) | [EPA Substance Registry System]
2H-1-Benzopyran-2-one, 4-methyl-7-(sulfooxy)-, potassium salt (15220-11-8) |
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [F ]
8-10-21 | [TSCA ]
Yes | [HS Code ]
29322090 |
| Hazard Information | Back Directory | [Chemical Properties]
Crystalline Solid | [Uses]
4-Methylumbelliferyl sulfate potassium salt is a fluorometric substrate for the determination of sulfatase. This substrate has been used in the discovery of tyrosine sulfotransferase inhibitors, particularly in P-selectin glycoprotein ligand-1 binding. This compound is virtually non-fluorescent until cleavage by sulfatase enzymes, then emits blue fluorescence (450 nm) with excitation at 360 nm. Use of this compound in high-throughput fluorescence based screening led to the discovery of several potent beta-arylsulfotransferase IV (beta-AST-IV) inhibitors. | [Uses]
Met-enkephalin analog found in opioid extracts of brain and adrenal chromaffin cells that is an artifact generated by trichloroacetic acid extraction. MUS is used as a fluorimetric substrate for arylsulphatase enzyme. Subsitution of the hydroxyl group of 4-Methylumbelliferyl sulfate potassium salt causes the excitation wavelength of the umbelliferone to shift to shorter values and also brings about a decrease in fluorescence. Fluorescence: max. Abs = 334 mm; max. Em. = 370 mm
| [Biological Activity]
4-Methylumbelliferyl sulfate (4MUS) is capable of undergoing desulfation and involve in futile cycling with 4MU. It can be utilized to measure the arylsulfatase activity of several sulfatases. |
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