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ChemicalBook--->CAS DataBase List--->145572-44-7

145572-44-7

145572-44-7 Structure

145572-44-7 Structure
IdentificationBack Directory
[Name]

13,14-Didehydromatridin-15-one
[CAS]

145572-44-7
[Synonyms]

SOPHOCARPINE
Matridine-13-ene-15-one
Sophocarpine Monohydrate
13,14-didehydromatridin-15-one
(6AS,11AR,11BR,11CS)-2,3,5,6,6A,7,11,11A,11B,11C-DECAHYDRO-1H,4H-3A,7A-DIAZA-BENZO[DE]ANTHRACEN-8-ONE
(41S,7aS,13aR,13bR)-2,3,41,6,7,7a,8,13,13a,13b-Decahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one hydrate
[Molecular Formula]

C15H22N2O
[MDL Number]

MFCD00274555
[MOL File]

145572-44-7.mol
[Molecular Weight]

246.35
Chemical PropertiesBack Directory
[Melting point ]

8l-2°C
[storage temp. ]

-20°C Freezer
[solubility ]

Acetone; Dichloromethane
[form ]

Solid
[color ]

Pale brownish
Safety DataBack Directory
[HS Code ]

2939.80.0000
Hazard InformationBack Directory
[Description]

A tetracyclic alkaloid present in Sophora species, this base crystallizes from H20 as the monohydrate, m.p. 54-5°C which becomes anhydrous in vacuo. It has [α]18D - 29.44° (EtOH) and yields the following salts: hydrochloride, m.p. > 300°C; hydriodide, m.p. 277-9°C; aurichloride, m.p. l66-7°C; platinichloride, m.p. 207-212°C (dec.); picrate, m.p. ISS-7°C and the methiodide, m.p. 200-2°C. Reduction of the base by electrolysis yields a crystalline, volatile base, ClsH26N2, b.p. l53-4°C/5 mm; [α]D - 26.2° (EtOH) and giving a methiodide with a melting point above 300°C. Attempted degradation by the Hofmann process has proved unsuccessful.
[Uses]

Sophocarpine Monohydrate alleviates non-alcoholic steatohepatitis, which is a resultant effect of non-alcoholic fatty lifer disease. Admission of this compound results in a decrease in liver weight and serum lipids. Antiviral agent, Sophocarpine also displays a profound effect against coxsackievirus and therapeutical effects of viral myocarditis.
[IC 50]

PI3K
[References]

Orekhov, Proskurnina., Ber., 67,77 (1934)
Proskurnina, Kuzuvkov., Dokl. Akad. Nauk SSSR, 91, 1145 (1953)
Okuda et al., Chern. & Ind., 1326 (1962)
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