| Identification | More | [Name]
Exenatide acetate | [CAS]
141732-76-5 | [Synonyms]
ENFUVIRTIDE ACETATE
EXENATIDE ACETATE
Exenatide
His-Gly-Gly-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH{2}
EXENATIDE ACETATE(EXENDIN-4) | [EINECS(EC#)]
1592732-453-0 | [Molecular Formula]
C184H282N50O60S.C2H4O2 | [MDL Number]
MFCD08704781 | [MOL File]
141732-76-5.mol | [Molecular Weight]
4262.67 |
| Chemical Properties | Back Directory | [Melting point ]
>209°C (dec.) | [storage temp. ]
Refrigerator, under inert atmosphere | [solubility ]
Acetonitrile (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Sequence]
H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 | [CAS DataBase Reference]
141732-76-5(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
A 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus. Application of exenatide causes an increase in acinar cAMP without stimulating amylase release. As an incretin mimetic, exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide has found use as a medication of diabetes II. | [Clinical Use]
39-peptide known as an incretin mimetic;
an agonist of glucagon-like peptide-1,
used adjunctively in type II diabetes
mellitus. | [Drug interactions]
Potentially hazardous interactions with other drugs
Anticoagulants: possibly enhances anticoagulant
effect of warfarin.
Other nephrotoxins: avoid concomitant use. | [Metabolism]
Exenatide is eliminated through the kidneys by
glomerular filtration followed by proteolytic degradation. |
|
|