| Identification | Back Directory | [Name]
ML417 | [CAS]
1386162-69-1 | [Synonyms]
ML417
Methanone, 1H-indol-2-yl[4-[2-(4-methoxyphenoxy)ethyl]-1-piperazinyl]- | [Molecular Formula]
C22H25N3O3 | [MDL Number]
MFCD32693923 | [MOL File]
1386162-69-1.mol | [Molecular Weight]
379.45 |
| Chemical Properties | Back Directory | [Boiling point ]
613.3±55.0 °C(Predicted) | [density ]
1.231±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
16.11±0.30(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
ML417 is a blood-brain barrier permeablepotent and highly selective agonist of D3 dopamine receptor (D3R) with very limited cross-reactivity at other GPCRs. ML417 potently induces G-protein activationD3R-mediated b-arrestin translocation and pERK phosphorylation. It does not activate other dopamine receptors. ML417 protect D3R-expressing dopaminergic neurons from 6-OHDA induced cell death. |
|
| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
|