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ChemicalBook--->CAS DataBase List--->2070015-10-8

2070015-10-8

    • 2070015-10-8 Structure

    2070015-10-8 Structure
    IdentificationBack Directory
    [Name]

    ML 204
    [CAS]

    2070015-10-8
    [Synonyms]

    ML204 hydrochloride,ML-204 hydrochloride
    [Molecular Formula]

    C15H19ClN2
    [MDL Number]

    MFCD30377212
    [MOL File]

    2070015-10-8.mol
    [Molecular Weight]

    262.78
    Chemical PropertiesBack Directory
    [storage temp. ]

    Inert atmosphere,2-8°C
    [form ]

    Solid
    [color ]

    White to off-white
    Hazard InformationBack Directory
    [Biological Activity]

    ML204 is a potent and selective inhibitor of TRPC4/TRPC5 channels with 20-fold selectivity over TRPC6, without affecting other TRP channels and voltage-gated sodium, potassium or Ca2+ channels.
    [in vitro]

    ML204 inhibits TRPC4β-mediated intracellular Ca 2+ rise with an IC 50 value of 0.96 μM (HEK293 cells) and exhibits 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation.
    It blocks TRPC4β activity induced through either G i/o stimulation by μ-opioid, 5HT 1A serotonin, and M 2 muscarinic receptors or G q/11 stimulation by the endogenous M 3 -like muscarinic receptors.
    It blocks LPS-induced TRPC5 channel activity.

    [in vivo]

    ML204 (1 mg/kg; sc; twice a day; for 5 days) causes mortality associated with exacerbated hypothermia and decreases peritoneal leukocyte numbers and cytokines in LPS-injected mice.

    < td class="col2"> Subcutaneous injection, twice a day, for 5 days (prior to LPS injection) < td class="col2"> Induces mortality associated with increased hypothermia in mice with LPS-induced systemic inflammatory response.
    Animal Model: Nonfasted male C57BL/6 (2-3 months)
    Dosage: 1 mg/kg
    Administration:
    Result:
    [target]

    TRPC4

    TRPC5

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