| Identification | Back Directory | [Name]
m-PEG10-amine | [CAS]
1383658-09-0 | [Synonyms]
m-PEG10-amine
3,6,9,12,15,18,21,24,27,30-Decaoxahentriacontan-1-amine | [Molecular Formula]
C21H45NO10 | [MDL Number]
MFCD27977522 | [MOL File]
1383658-09-0.mol | [Molecular Weight]
471.58 |
| Hazard Information | Back Directory | [Description]
m-PEG10-amine is reactive with activated NHS esters to form stable aminde bond. The hydrophilic PEG spacer increases solubility in aqueous media. | [Biological Activity]
m-PEG10-amine is a non-cleavable ADC linker containing 10 units of PEG, which can be used for the synthesis of antibody drug conjugates (ADCs). It is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules. | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. | [target]
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